Evidence map›Paper›PMID 29738736›Full record

ReviewHormones and behavior2018

Organic cation transporter 3: A cellular mechanism underlying rapid, non-genomic glucocorticoid regulation of monoaminergic neurotransmission, physiology, and behavior.

Paul J Gasser, Christopher A Lowry

Open access · greenAbstract readReview
In one paragraph

Review in Hormones and behavior, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
3.4field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 37 citations in OpenAlex.

  1. Review
  2. Article
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  6. Review
  7. Article
  8. Chronically dysregulated corticosterone impairs dopaminergic transmission in the dorsomedial striatum by sex-divergent mechanisms.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023
    Article
  9. Review
  10. Article
  11. Article
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  13. Review
  14. Functional inhibition of Oct leads to HNF4α upregulation.Experimental and therapeutic medicine · 2021
    Article
  15. Review
  16. Review
  17. Review
  18. Review
  19. Roles for the uptakeNeurochemistry international · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Paul J GasserDepartment of Biomedical Sciences, Marquette University, Milwaukee, WI 53201, USA. Electronic address: paul.gasser@marquette.edu.
Christopher A LowryDepartment of Integrative Physiology and Center for Neuroscience, University of Colorado Boulder, Boulder, CO 80309, USA; Department of Physical Medicine and Rehabilitation, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA; Rocky Mountain Mental Illness Research Education and Clinical Center (MIRECC), Denver Veterans Affairs Medical Center (VAMC), Denver, CO 80220, USA; Military and Veteran Microbiome Consortium for Research and Education (MVM-CoRE), Denver, CO 80220, USA. Electronic address: christopher.lowry@colorado.edu.
Marquette University · USUniversity of Colorado Boulder · US

Funding

Glucocorticoid regulation of dopamine clearance, cocaine seeking, and rewardR01DA032895 · NIDA · MARQUETTE UNIVERSITY · PI BAKER, DAVID A, GASSER, PAUL JOSEPH · 2014 to 2018
$2.0M
Mycobacterium vaccae and stress resilience: Neural mechanismsR21MH116263 · NIMH · UNIVERSITY OF COLORADO · PI FRANK, MATTHEW G, LOWRY, CHRISTOPHER A · 2018 to 2019
$424k
Biological Signature and Safety of an Immunomodulatory Probiotic Intervention for Veterans with Co-Occuring Mild TBI and PTSDI21RX002232 · VA · VA EASTERN COLORADO HEALTH CARE SYSTEM · PI BRENNER, LISA A · 2016 to 2018
–
NIDA NIH HHS R01 DA032895NIMH NIH HHS R21 MH116263RRD VA I21 RX002232
6 · The paper itself

Abstract

Contribution to Special Issue on Fast effects of steroids. Corticosteroid hormones act at intracellular glucocorticoid receptors (GR) and mineralocorticoid receptors (MR) to alter gene expression, leading to diverse physiological and behavioral responses. In addition to these classical genomic effects, corticosteroid hormones also exert rapid actions on physiology and behavior through a variety of non-genomic mechanisms, some of which involve GR or MR, and others of which are independent of these receptors. One such GR-independent mechanism involves corticosteroid-induced inhibition of monoamine transport mediated by "uptake

Indexed as

BehaviorAnimalsBrainCorticosteroneGlucocorticoidsHumansNeuronsOrganic Cation Transport ProteinsSynaptic TransmissionCorticosteroneGlucocorticoidsOrganic Cation Transport ProteinsCorticosteroneDopamineEpinephrineExtraneuronal monoamine transporterHistaminemember 3NorepinephrineOCT3Organic cation transporter 3Serotoninslc22a3Solute carrier family 22 (organic cation transporter)

Identifiers

PMID29738736
PMCPMC7137088
OpenAlexW2802387589

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.