ArticlePloS one2018
Distinct characteristics and outcomes in elderly-onset IgA vasculitis (Henoch-Schönlein purpura) with nephritis: Nationwide cohort study of data from the Japan Renal Biopsy Registry (J-RBR).
Article in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed, 23 citations in OpenAlex.
- Clinical characteristics and renal risk stratification of mixed-type IgA vasculitis: a large-volume study.Frontiers in immunology · 2026Article
- Mucosal Fibrosis on Biopsy Predicting Intestinal Perforation in Adult-Onset IgA Vasculitis: A Case Report.Cureus · 2025Article
- Dynamics of urine proteomics biomarker and disease progression in patients with IgA nephropathy.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2023Article
- Viral Infections May Be Associated with Henoch-Schönlein Purpura.Journal of clinical medicine · 2023Review
- Immunoglobulin a (IgA) Vasculitis in the Elderly.Cureus · 2023Article
- Article
- IgA Vasculitis in an Oldest-old Patient Successfully Treated with Glucocorticoid.Internal medicine (Tokyo, Japan) · 2022Article
- Efficacy and safety of low-dose corticosteroid with azathioprine in the treatment of elderly-onset IgA vasculitis with nephritis.BMJ case reports · 2021Article
- Henoch-Schonlein Purpura Presenting as Upper Gastrointestinal Bleed in an Adult Patient.Cureus · 2021Article
- Low-dose corticosteroid with mizoribine might be an effective therapy for elderly-onset ISKDC grade VI IgA vasculitis.CEN case reports · 2021Article
- Article
- The revised version 2018 of the nationwide web-based registry system for kidney diseases in Japan: Japan Renal Biopsy Registry and Japan Kidney Disease Registry.Clinical and experimental nephrology · 2020Article
- Adult-Onset Immunoglobulin A Vasculitis.ACG case reports journal · 2020Article
- Management of End-stage Renal Disease Associated with Systemic Rheumatic Diseases.JMA journal · 2020Review
- Gastrointestinal bleeding is associated with renal prognosis in adult patients with IgA vasculitis with nephritis.Journal of general and family medicine · 2020Article
- Case of Gut Necrosis in Adult-Onset Immunoglobulin A Vasculitis (Henoch-Schönlein Purpura).Journal of investigative medicine high impact case reportsArticle
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14 authors at 14 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundThe clinical presentation and prognosis of adult and elderly patients with IgA vasculitis (Henoch-Schönlein purpura) accompanied by nephritis (IgAV-N) have not been investigated in detail. We therefore surveyed the features and outcomes of IgAV-N based on nationwide data derived from the Japan Renal Biopsy Registry (J-RBR).
methodsThis multi-center cohort study compared the clinicopathological parameters at diagnosis, initial therapies and outcomes between 106 adult (age 19-64 years) and 46 elderly (≥65 years) patients with IgAV-N who were registered in the J-RBR between 2007 and 2012. The primary end-points comprised a 50% increase in serum creatinine (sCr) values or end-stage kidney disease. Factors affecting a decrease in renal function were assessed using Cox proportional hazards models.
resultsRates of hypertension, impaired renal function, hypoalbuminemia and crescentic glomerulonephritis were significantly higher among the elderly, than the adult patients. About 80% and 60% of the patients in both groups were respectively treated with corticosteroid and a renin-angiotensin system (RAS) blockade. Both groups had favorable renal survival rates for nine years (93.6% and 91.4% of the adult and elderly patients, respectively). Significantly more elderly than adult patients developed a 50% increase in sCr during a mean observation period of 3.9 years (21.7% vs. 4.7%, p = 0.012), and significantly fewer elderly, than adult patients achieved clinical remission (23.9% vs. 46.2%, p = 0.016). Multivariate analysis selected advanced age (≥65 years) and lower serum albumin values as independent prognostic factors for a decline in renal function, whereas steroid pulse therapy helped to preserve renal function.
conclusionsThe renal prognosis of adult and elderly patients with IgAV-N was favorable when treated aggressively with corticosteroid and RAS blockade. However, the course of renal function should be carefully monitored in patients aged over 65 years and those with hypoalbuminemia.
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