ArticlePloS one2018
Intraretinal changes in idiopathic versus diabetic epiretinal membranes after macular peeling.
Article in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 36 citations in OpenAlex.
- Comparison of retinal thickness and choroidal vascularity index after vitrectomy in idiopathic versus diabetic epiretinal membrane.BMC ophthalmology · 2026Article
- Dexamethasone implant vs. anti-VEGF for diabetic macular edema with epiretinal membrane: short-term outcomes.International journal of retina and vitreous · 2026Article
- Unveiling the limitations of OCT-based classification in diabetic epiretinal membranes: a call for integrative vascular and structural assessment with OCT-A.International ophthalmology · 2025Article
- Vitrectomy for Epiretinal Membrane Peeling in Patients with Diabetic Retinopathy-Functional and Morphological Outcome.Journal of clinical medicine · 2025Article
- Hyperreflective Foci in the Ectopic Inner Foveal Layer of Advanced Idiopathic Epiretinal Membranes.Investigative ophthalmology & visual science · 2025Article
- Elevated hyperreflective foci as a novel characteristic in idiopathic epiretinal membrane by optical coherence tomography angiography.BMC ophthalmology · 2025Article
- Temperature control during pars plana vitrectomy.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2025Article
- Quantitative analysis of idiopathic epiretinal membrane traction: an updated version of the relaxation index.Frontiers in ophthalmology · 2025Article
- Pharmacological adjuvants for diabetic vitrectomy surgery.World journal of methodology · 2024Review
- The effect of diabetes on short-term outcomes following epiretinal membrane surgery.International ophthalmology · 2024Article
- Anatomical changes in idiopathic epiretinal membrane at 2-year follow-up assessed using spectral domain optical coherence tomography and optical coherence tomographic angiography.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2024Article
- Diabetic Retinopathy: Soluble and Imaging Ocular Biomarkers.Journal of clinical medicine · 2023Review
- Functional and Anatomical Outcomes of Pars Plana Vitrectomy for Epiretinal Membrane in Patients with Uveitis.Diagnostics (Basel, Switzerland) · 2022Article
- Editorial: Imaging in Ophthalmology.Journal of clinical medicine · 2022Article
- Retinal and Corneal Changes Associated with Intraocular Silicone Oil Tamponade.Journal of clinical medicine · 2022Review
- Epiretinal Membrane Peeling in Eyes with Retinal Vein Occlusion: Visual and Morphologic Outcomes.Ophthalmology and therapy · 2022Article
- Increased risk of postsurgical macular edema in high stage idiopathic epiretinal membranes.Eye and vision (London, England) · 2021Article
- Article
- Vitreous and intraretinal macular changes in diabetic macular edema with and without tractional components.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2019Review
- Correction: Intraretinal changes in idiopathic versus diabetic epiretinal membranes after macular peeling.PloS one · 2018Article
Corrections and comments
- Erratum issued
Authors and funding
9 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionEpiretinal traction is not responsible only for epiretinal but also intraretinal changes. This study aims to describe structural and vascular intraretinal changes after macular peeling in idiopathic (iERM) vs diabetic ERM (dERM).
methodsWe conducted a prospective interventional study on forty-two eyes, 23 with iERMs and 19 with dERMs, undergoing ERM-ILM peeling. We performed SD-OCT preoperatively, 1 and 6 months postoperatively to assess central macular thickness (CMT), intraretinal cysts (IC) and/or continuous ectopic inner foveal layers (CEIFL), superficial and deep capillary free zone (CFZ) area on OCT-A. Glial fibrillary acidic protein (GFAP), as a Müller cells marker, was detected immunohistochemically on ILM specimens, to assess Müller cells iatrogenic damage.
resultsThe CEIFLs were significantly more common in iERMs (12 (52.2%) in iERMs vs 2 (10.5%) in dERMs, p = 0.004), whereas ICs in dERMs (6 (26.1%) in iERMs vs 17 (89.5%) in dERMs, p<0.001). Median preoperative and postoperative BCVA was 20/50 [20/40-20/66] and 20/33 [20/25-20/40] in iERMs and 20/100 [20/66-20/200] and 20/50 [20/50-20/66] in dERMs, respectively. Median preoperative and postoperative CMT was 423 [370-488] and 364 [329-382] μm in iERM group and 465 [447-503] and 378 [359-433] μm in dERM group, respectively. The BCVA improvement and reduction of CMT thickness were significant in both groups (p<0.001). The presence of CEIFL was associated with lower BCVA in iERMs. Deep CFZ network significantly increased only in dERMs, passing from 0.34 [0.29-0.42] mm2 preoperatively to 0.56 [0.46-0.6] mm2 at 6-month follow-up (p<0.001). The GFAP expression was significantly higher in dERMs (p = 0.001).
conclusionThe intraretinal changes are different in iERMs and dERMs, as increased expression of CEIFLs in iERMs vs ICs in dERMs. The CEIFLs are associated with worse anatomical and functional outcomes in iERMs, whereas GFAP espression in peeled ILMs is higher in dERMs.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.