Evidence map›Paper›PMID 29738516›Full record

ArticleInternational journal of molecular sciences2018

The Bacterial Toxin CNF1 Induces Activation and Maturation of Human Monocyte-Derived Dendritic Cells.

Laura Gall-Mas, Alessia Fabbri, Martin R J Namini, Michael Givskov, Carla Fiorentini, Thorbjørn Krejsgaard

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 2 pooled it
0.8field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 2 syntheses or guidelines pooled it, 10 citations in OpenAlex.

  1. Pooled it
  2. Effects of theInternational journal of molecular sciences · 2021
    Pooled it
  3. Article
  4. The footprint of gut microbiota in gallbladder cancer: a mechanistic review.Frontiers in cellular and infection microbiology · 2024
    Review
  5. Article
  6. Article
  7. Article
  8. Immunomodulatory properties of CNF1 toxin fromAmerican journal of cancer research · 2022
    Review
  9. Review
  10. RNA-Dependent Regulation of Virulence in Pathogenic Bacteria.Frontiers in cellular and infection microbiology · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Laura Gall-MasDepartment of Immunology and Microbiology, University of Copenhagen, Nørre Alle 14, 2200 Copenhagen, Denmark. lgmas@sund.ku.dk.ORCID 0000-0002-0420-2334
Alessia FabbriItalian Center for Global Health, Istituto Superiore di Sanitá; Viale Regina Elena 299, 00161 Rome, Italy. alessia.fabbri@iss.it.
Martin R J NaminiDepartment of Immunology and Microbiology, University of Copenhagen, Nørre Alle 14, 2200 Copenhagen, Denmark. mnamini@sund.ku.dk.
Michael GivskovCosterton Biofilm Center, Department of Immunology and Microbiology, University of Copenhagen, Nørre Alle 14, 2200 Copenhagen, Denmark. mgivskov@sund.ku.dk.
Carla FiorentiniItalian Center for Global Health, Istituto Superiore di Sanitá; Viale Regina Elena 299, 00161 Rome, Italy. carla.fiorentini@iss.it.
Thorbjørn KrejsgaardDepartment of Immunology and Microbiology, University of Copenhagen, Nørre Alle 14, 2200 Copenhagen, Denmark. thorkr@sund.ku.dk.
University of Copenhagen · DKIstituto Superiore di Sanità · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cytotoxic necrotizing factor 1 (CNF1) is a bacterial protein toxin primarily expressed by pathogenic

Indexed as

Adjuvants, ImmunologicBacterial ToxinsCell SurvivalDendritic CellsEscherichia coliEscherichia coli ProteinsHumansInflammationMonocytesrho GTP-Binding ProteinsAdjuvants, ImmunologicBacterial Toxinscytotoxic necrotizing factor type 1Escherichia coli Proteinsrho GTP-Binding Proteinsanti-virulence immunitybacterial toxinsCNF1cytokine expressiondendritic cellseffector-triggered immunityinflammationmoDCsRho GTPasesT-cell activation

Identifiers

PMID29738516
PMCPMC5983691
OpenAlexW2801413237

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.