ArticleMenopause (New York, N.Y.)2018
Design and protocol of Estrogenic Regulation of Muscle Apoptosis (ERMA) study with 47 to 55-year-old women's cohort: novel results show menopause-related differences in blood count.
Article in Menopause (New York, N.Y.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed.
- Impact of Whole Body Electromyostimulation on Velocity, Power and Body Composition in Postmenopausal Women: A Randomized Controlled Trial.International journal of environmental research and public health · 2020Trial
- Effects of Whole-Body Electromyostimulation on Physical Fitness in Postmenopausal Women: A Randomized Controlled Trial.Sensors (Basel, Switzerland) · 2020Trial
- Methodological Considerations for Studies in Sport and Exercise Science with Women as Participants Part II: Guidance for Applied Studies in Elite Female Athletes.Sports medicine (Auckland, N.Z.) · 2026Article
- Article
- Effect of Age and Sex on Lower Extremity Power Production Capacity Throughout the Lifespan Based on 30 217 Finnish Participant Data.Scandinavian journal of medicine & science in sports · 2026Article
- Genetic, lifestyle and environmental influences on health: a Finnish biobank recall study protocol (BioRecall).BMJ open · 2026Article
- Vitamin D sufficiency and its relationship with muscle health across the menopausal transition and aging: Finnish cohorts of middle-aged women and older women and men.European journal of clinical nutrition · 2025Article
- The acute exercise response of peripheral blood mononuclear cells and their bioenergetic function in women with high and low systemic estradiol levels.Physiological reports · 2025Article
- Body composition and functional capacity as determinants of physical activity in middle-aged and older adults: a cross-sectional analysis.European review of aging and physical activity : official journal of the European Group for Research into Elderly and Physical Activity · 2025Article
- Associations of Habitual Skeletal Loading with Bone Changes during the Menopausal Transition: A Follow-Up Study.Medicine and science in sports and exercise · 2025Article
- A mediating role of visceral adipose tissue on the association of health behaviours and metabolic inflammation in menopause: a population-based cross-sectional study.Scientific reports · 2025Article
- Trajectories of peripheral white blood cells count around the menopause: a prospective cohort study.BMC women's health · 2024Article
- Metabolic syndrome and epigenetic aging: a twin study.International journal of obesity (2005) · 2024Article
- Hematological Indices and Genetic Variants of Premature Ovarian Insufficiency: Machine Learning Approaches.Cardiovascular & hematological disorders drug targets · 2024Article
- Accelerometer-Measured Physical Activity Data Sets (Global Physical Activity Data Set Catalogue) That Include Markers of Cardiometabolic Health: Systematic Scoping Review.Journal of medical Internet research · 2023Article
- Systemic circulating microRNA landscape in Lynch syndrome.International journal of cancer · 2023Article
- Associations of cardiorespiratory fitness, body composition, and blood pressure with arterial stiffness in adolescent, young adult, and middle-aged women.Scientific reports · 2022Article
- Total and regional body adiposity increases during menopause-evidence from a follow-up study.Aging cell · 2022Article
- Metabolic health, menopause, and physical activity-a 4-year follow-up study.International journal of obesity (2005) · 2022Article
- Physical Performance During the Menopausal Transition and the Role of Physical Activity.The journals of gerontology. Series A, Biological sciences and medical sciences · 2021Article
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Authors and funding
9 authors.
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Abstract
objectiveThe multidisciplinary Estrogenic Regulation of Muscle Apoptosis (ERMA) study was designed to reveal how hormonal differences over the menopausal stages affect the physiological and psychological functioning of middle-aged women. This paper describes the protocol and nonrespondent analysis of ERMA and novel findings on menopausal differences in blood count variables and their association with female sex hormones.
methodsWomen aged 47 to 55 years were assigned to pre, early peri, late peri, and postmenopausal groups based on follicle-stimulating hormone (FSH) and bleeding diary. Multivariate linear regression models were constructed to estimate the association of 17β-estradiol (E2) and FSH with the blood count variables.
resultsIn all, 3,064 women returned the prequestionnaire (ERMA phase one), 1,393 donated blood samples and were assigned to the relevant menopausal group (phase two), and 914 completed phase three, which included physiological and psychological measurements. Nonrespondents were more likely than respondents to be obese, whereas the menopausal groups showed no mean differences in body mass index. Blood count variables, while being within clinical reference values, showed significant differences between groups. E2 and FSH were associated with the white blood cell (WBC) count and neutrophil-to-lymphocyte ratio.
conclusionsThe ERMA study was successful in recruiting and characterizing the menopausal status of a cohort sample of middle-aged women. The significant group differences found in the blood count variables and their associations with E2 and FSH verifies menopause-associated changes in WBC composition potentially being an early sign of low-grade inflammation that may develop later in life.
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