ArticleCell and tissue research1988
Immunohistochemical and ultrastructural localisation of peptide-containing nerves and myocardial cells in the human atrial appendage.
Article in Cell and tissue research, 1988. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 62 citations in OpenAlex.
- Distribution and morphology of CGRP-IR axons in flat-mounts of whole male and female mouse atria.Autonomic neuroscience : basic & clinical · 2025Article
- Neurokinin-3 receptor activation selectively prolongs atrial refractoriness by inhibition of a background KNature communications · 2018Article
- Angiotensinergic Innervation of the Human Right Atrium: Implications for Cardiac Reflexes.American journal of hypertension · 2018Article
- Concepts of neuroendocrine cardiology and neuroendocrine immunology, chemistry and biology of signal molecules.Neurochemical research · 2010Article
- Role of substance P in viral myocarditis in mice.Heart and vessels · 2010Article
- Localisation and quantitation of autonomic innervation in the porcine heart I: conduction system.Journal of anatomy · 1999Article
- Postmortem changes in the immunohistochemical demonstration of nerves in human ventricular myocardium.Journal of anatomy · 1998Article
- Natriuretic peptide immunoreactivity in nerve structures and Purkinje fibres of human, pig and sheep hearts.The Histochemical journal · 1997Article
- The innervation of the human myocardium at birth.Journal of anatomy · 1995Article
- Development of the peptidergic innervation of human heart.Journal of anatomy · 1993Article
- Protein gene product 9.5 and ubiquitin immunoreactivities in rat epididymis epithelium.Histochemistry · 1993Article
- Innervation of the human cardiac conduction system at birth.British heart journal · 1993Article
- Expression of the human neuropeptide tyrosine Y1 receptor.Proceedings of the National Academy of Sciences of the United States of America · 1993Article
- Immunocytochemical localisation of substance P-like nerves in the cardiac ganglia of the monkey (Macaca fascicularis).Journal of anatomy · 1992Article
- Atrial and brain natriuretic peptides share binding sites on cultured cells from the rat trachea.Cell and tissue research · 1991Article
- The morphology and location of atrial specific granules and the demonstration of atrial natriuretic factor in porcine, lapine and bovine heart by immunoelectronmicroscopy.Veterinary research communications · 1991Article
- Myocardial localization and isoforms of neural cell adhesion molecule (N-CAM) in the developing and transplanted human heart.The Journal of clinical investigation · 1990Article
- Autoradiographic localization of specific atrial natriuretic peptide binding sites on immunocytochemically identified cells in cultures from rat and guinea-pig hearts.Cell and tissue research · 1990Article
- Protein gene product 9.5-immunoreactive nerve fibres and cells in human skin.Cell and tissue research · 1990Article
- The intracardiac neurones of the fetal human heart in culture.Anatomy and embryology · 1990Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The innervation and myocardial cells of the human atrial appendage were investigated by means of immunocytochemical and ultrastructural techniques using both tissue sections and whole mount preparations. A dense innervation of the myocardium, blood vessels and endocardium was revealed with antisera to general neuronal (protein gene product 9.5 and synaptophysin) and Schwann cell markers (S-100). The majority of nerve fibres possessed neuropeptide Y immunoreactivity and were found associated with myocardial cells, around small arteries and arterioles at the adventitial-medial border and forming a plexus in the endocardium. Subpopulations of nerve fibres displayed immunoreactivity for vasoactive intestinal polypeptide, somatostatin, substance P and calcitonin gene-related peptide. In whole-mount preparations of endocardium, substance P and calcitonin gene-related peptide immunoreactivities were found to coexist in the same varicose nerve terminals. Ultrastructural studies revealed the presence of numerous varicose terminals associated with myocardial, vascular smooth muscle and endothelial cells. Neuropeptide Y immunoreactivity was localised to large electron-dense secretory vesicles in nerve terminals which also contained numerous small vesicles. Atrial natriuretic peptide immunoreactivity occurred exclusively in myocardial cells where it was localised to large secretory vesicles. The human atrial appendage comprises a neuroendocrine complex of peptide-containing nerves and myocardial cells producing ANP.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.