ArticleACS applied materials & interfaces2018
Exclusive Liquid Repellency: An Open Multi-Liquid-Phase Technology for Rare Cell Culture and Single-Cell Processing.
Article in ACS applied materials & interfaces, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- Exclusive liquid repellency isolation (ELRi) microliter scale isolation technique unmasks T-cell migration defects to CCL21 in pediatric asthma.bioRxiv : the preprint server for biology · 2026Article
- Phase I multi-center clinical and biomarker study of the dual-action androgen receptor inhibitor ONCT-534.Investigational new drugs · 2026Article
- Multiplexed luminal tissue constructs with reconfigurable barriers for dynamic modeling of multi-tissue interactions.Advanced materials technologies · 2025Article
- In Vitro Monitoring of Babesia microti Infection Dynamics in Whole Blood Microenvironments.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Lossless Altered Histone Modification Analysis System (LAHMAS).Lab on a chip · 2025Article
- Confinement by Liquid-Liquid Interface Replicates In Vivo Neutrophil Deformations and Elicits Bleb-Based Migration.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Combining Top-Down and Bottom-Up: An Open Microfluidic Microtumor Model for Investigating Tumor Cell-ECM Interaction and Anti-Metastasis.Small (Weinheim an der Bergstrasse, Germany) · 2025Article
- Co-zorbs: Motile, multispecies biofilms aid transport of diverse bacterial species.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Microliter Whole Blood Neutrophil Assay Preserving Physiological Lifespan and Functional Heterogeneity.Small methods · 2024Article
- Co-zorbs: Motile, multispecies biofilms aid transport of diverse bacterial species.bioRxiv : the preprint server for biology · 2024Article
- PTP1B phosphatase dampens iPSC-derived neutrophil motility and antimicrobial function.Journal of leukocyte biology · 2024Article
- Visualization-enhanced under-oil open microfluidic system for in situ characterization of multi-phase chemical reactions.Nature communications · 2024Article
- The effect of whole blood logistics on neutrophil non-specific activation and kinetics ex vivo.Scientific reports · 2024Article
- Miniaturizing chemistry and biology using droplets in open systems.Nature reviews. Chemistry · 2023Review
- Under-oil open microfluidic systems for rapid phenotypic antimicrobial susceptibility testing.Lab on a chip · 2023Article
- Interfacial tension driven open droplet microfluidics.Advanced materials interfaces · 2023Article
- Reconfigurable Microfluidic Circuits for Isolating and Retrieving Cells of Interest.ACS applied materials & interfaces · 2022Article
- Under-Oil Autonomously Regulated Oxygen Microenvironments: A Goldilocks Principle-Based Approach for Microscale Cell Culture.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Article
- Volumeless reagent delivery: a liquid handling method for adding reagents to microscale droplets without increasing volume.Lab on a chip · 2022Article
- Social motility of biofilm-like microcolonies in a gliding bacterium.Nature communications · 2021Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
The concept of high liquid repellency in multi-liquid-phase systems (e.g., aqueous droplets in an oil background) has been applied to areas of biomedical research to realize intrinsic advantages not available in single-liquid-phase systems. Such advantages have included minimizing analyte loss, facile manipulation of single-cell samples, elimination of biofouling, and ease of use regarding loading and retrieving of the sample. In this paper, we present generalized design rules for predicting the wettability of solid-liquid-liquid systems (especially for discrimination between exclusive liquid repellency (ELR) and finite liquid repellency) to extend the applications of ELR. We then apply ELR to two model systems with open microfluidic design in cell biology: (1) in situ underoil culture and combinatorial coculture of mammalian cells in order to demonstrate directed single-cell multiencapsulation with minimal waste of samples as compared to stochastic cell seeding and (2) isolation of a pure population of circulating tumor cells, which is required for certain downstream analyses including sequencing and gene expression profiling.
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Registered trials
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