Evidence map›Paper›PMID 29737910›Full record

ArticleCancer biology & therapy2018

In Vitro and In Vivo evaluation of a novel folate-targeted theranostic nanoemulsion of docetaxel for imaging and improved anticancer activity against ovarian cancers.

Niravkumar R Patel, Aleksandr Piroyan, Srinivas Ganta, Allison B Morse, Katie M Candiloro, April L Solon, Abbegail H Nack, Corin A Galati, Collete Bora, Marisa A Maglaty and 5 more

Open access · bronzeAbstract read
In one paragraph

Article in Cancer biology & therapy, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.5field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 41 citations in OpenAlex.

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  7. Efficacy analysis of targeted nanodrug for non-small cell lung cancer therapy.Frontiers in bioengineering and biotechnology · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 2 institutions in 1 country.

Niravkumar R Patela Nemucore Medical Innovations, Inc. , Wellesley , MA.
Aleksandr Piroyana Nemucore Medical Innovations, Inc. , Wellesley , MA.
Srinivas Gantaa Nemucore Medical Innovations, Inc. , Wellesley , MA.
Allison B Morsea Nemucore Medical Innovations, Inc. , Wellesley , MA.
Katie M Candiloroa Nemucore Medical Innovations, Inc. , Wellesley , MA.
April L Solona Nemucore Medical Innovations, Inc. , Wellesley , MA.
Abbegail H Nacka Nemucore Medical Innovations, Inc. , Wellesley , MA.
Corin A Galatia Nemucore Medical Innovations, Inc. , Wellesley , MA.
Collete Boraa Nemucore Medical Innovations, Inc. , Wellesley , MA.
Marisa A Maglatyb Molecular Therapeutics Program, Fox Chase Cancer Center , 333 Cottman Avenue, Philadelphia , PA.
Shane W O'Brienb Molecular Therapeutics Program, Fox Chase Cancer Center , 333 Cottman Avenue, Philadelphia , PA.
Samuel Litwinb Molecular Therapeutics Program, Fox Chase Cancer Center , 333 Cottman Avenue, Philadelphia , PA.
Barbara Davisa Nemucore Medical Innovations, Inc. , Wellesley , MA.
Denise C Connollyb Molecular Therapeutics Program, Fox Chase Cancer Center , 333 Cottman Avenue, Philadelphia , PA.
Timothy P Colemana Nemucore Medical Innovations, Inc. , Wellesley , MA.
Nemucore Medical Innovations (United States) · USFox Chase Cancer Center · US

Funding

WORD PROCESSING CENTER--COREP30CA006927 · NCI · RESEARCH INST OF FOX CHASE CAN CTR · PI Margaret von Mehren · 1985 to 2026
$138.8M
Physico-Chemical Nanocharacterization CoreU54CA151881 · NCI · NORTHEASTERN UNIVERSITY · PI MINKO, TAMARA · 2010 to 2014
$12.4M
Integrated Image-Guided Targeted Therapy for Refractory Ovarian CancerR01CA158881 · NCI · NEMUCORE MEDICAL INNOVATIONS, INC. · PI AMIJI, MANSOOR M., COLEMAN, TIMOTHY P · 2011 to 2015
$2.9M
The Role of HEF1 in Ovarian Cancer Development, Progression, and MetastasisR01CA136596 · NCI · RESEARCH INST OF FOX CHASE CAN CTR · PI CONNOLLY, DENISE C · 2009 to 2013
$1.6M
NCI NIH HHS P30 CA006927NCI NIH HHS R01 CA136596NCI NIH HHS R01 CA158881NCI NIH HHS U54 CA151881
6 · The paper itself

Abstract

Ovarian cancer ranks fifth in cancer related deaths for women in USA. The high mortality rate associated with ovarian cancer is due to diagnosis at later stages of disease and the high recurrence rate of 60-80%. Recurrent ovarian cancers are more likely to present as multidrug resistance (MDR) leading to unfavorable response from 2

Indexed as

AnimalsAntineoplastic AgentsCell Line, TumorDisease Models, AnimalDocetaxelDrug CarriersEmulsionsEndocytosisFemaleFolate Receptor 1Folic AcidGadoliniumHumansMagnetic Resonance ImagingMiceMice, Inbred C57BLAntineoplastic AgentsDocetaxelDrug CarriersEmulsionsFolate Receptor 1Folic AcidFOLR1 protein, humanGadoliniumdocetaxelfolate receptor-alphafolic acidnanoemulsionsOvarian cancertheranostic

Identifiers

PMID29737910
PMCPMC5989790
OpenAlexW2799951892

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.