Evidence map›Paper›PMID 29737479›Full record

ArticleNeurochemical research2018

Locomotor Treadmill Training Promotes Soleus Trophism by Mammalian Target of Rapamycin Pathway in Paraplegic Rats.

Caroline Cunha do Espírito Santo, Daniela Dal Secco, Anamaria Meireles, Gabriel Ribeiro de Freitas, Franciane Bobinski, Mauricio Peña Cunha, Ana Lúcia Severo Rodrigues, Alessandra Swarowsky, Adair Roberto Soares Santos, Jocemar Ilha

Open access · greenAbstract read
PubMed Publisher
In one paragraph

Article in Neurochemical research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 8 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Caroline Cunha do Espírito SantoPrograma de Pós-graduação em Fisioterapia, Centro de Ciências da Saúde e do Esporte (CEFID), Universidade do Estado de Santa Catarina (UDESC), Florianópolis, SC, Brazil.
Daniela Dal SeccoPrograma de Pós-Graduação em Neurociências, Laboratório de Neurobiologia da Dor e da Inflamação (LANDI), Departamento de Ciências Fisiológicas, Universidade Federal de Santa Catarina (UFSC), Florianópolis, SC, Brazil.
Anamaria MeirelesPrograma de Pós-graduação em Fisioterapia, Centro de Ciências da Saúde e do Esporte (CEFID), Universidade do Estado de Santa Catarina (UDESC), Florianópolis, SC, Brazil.
Gabriel Ribeiro de FreitasPrograma de Pós-graduação em Fisioterapia, Centro de Ciências da Saúde e do Esporte (CEFID), Universidade do Estado de Santa Catarina (UDESC), Florianópolis, SC, Brazil.
Franciane BobinskiNúcleo de Pesquisa em Lesão Medular (NULEME), Laboratório de Pesquisa Experimental (LAPEx), Departamento de Fisioterapia, CEFID, UDESC, Florianópolis, SC, Brazil.
Mauricio Peña CunhaLaboratório de Neurobiologia da Depressão, Departamento de Bioquímica, UFSC, Florianópolis, SC, Brazil.
Ana Lúcia Severo RodriguesLaboratório de Neurobiologia da Depressão, Departamento de Bioquímica, UFSC, Florianópolis, SC, Brazil.
Alessandra SwarowskyPrograma de Pós-graduação em Fisioterapia, Centro de Ciências da Saúde e do Esporte (CEFID), Universidade do Estado de Santa Catarina (UDESC), Florianópolis, SC, Brazil.
Adair Roberto Soares SantosPrograma de Pós-Graduação em Neurociências, Laboratório de Neurobiologia da Dor e da Inflamação (LANDI), Departamento de Ciências Fisiológicas, Universidade Federal de Santa Catarina (UFSC), Florianópolis, SC, Brazil.
Jocemar IlhaPrograma de Pós-graduação em Fisioterapia, Centro de Ciências da Saúde e do Esporte (CEFID), Universidade do Estado de Santa Catarina (UDESC), Florianópolis, SC, Brazil. jocemar.ilha@udesc.br.ORCID http://orcid.org/0000-0002-6300-4696
Universidade do Estado de Santa Catarina · BRUniversidade Federal de Santa Catarina · BR

Funding

Fundação de Amparo à Pesquisa e Inovação do Estado de Santa Catarina TO 2013TR003379
6 · The paper itself

Abstract

Assisted-treadmill training, may be helpful in promoting muscle mass preservation after incomplete spinal cord injury (SCI). However, biological mechanism involved in this process is still not fully understood. This study investigated the effects of locomotor treadmill training on muscle trophism mediated by protein kinase B (Akt)/mammalian target of rapamycin (mTOR)/p70 ribosomal protein S6 kinase (p70S6K) in paraplegic rats. Adult female Wistar rats underwent an incomplete thoracic SCI induced by compression using an aneurysm clip. After 7 days, injured animals started a 3-week locomotor treadmill training with body weight-support and manual step help. Soleus trophism was measured by muscle weight and transverse myofiber cross-sectional area (CSA). An enzyme-linked immunosorbent assay (ELISA) and western blot analysis were used to detect brain-derived neurotrophic factor (BDNF), tropomyosin-related kinase B (TrkB), Akt, mTOR and p70S6K in paretic soleus. Trained animals did not show locomotor improved, but present an increase in muscle weight and myofiber CSA. Furthermore, the levels of Akt, p70S6K phosphorylation, mTOR and TrkB receptor were increased by training in soleus. In contrast, muscle BDNF levels were significantly reduced after training. The results suggest locomotor treadmill training partially reverts/prevents soleus muscle hypotrophy in rats with SCI. Furthermore, this study provided the first evidence that morphological muscle changes were caused by Akt/mTOR/p70S6K signaling pathway and TrkB up-regulation, which may increase the sensitivity of muscle, reducing autocrine signaling pathway demand of BDNF for cell growth.

Indexed as

AnimalsExercise TestFemaleLocomotionMuscle, SkeletalMuscular AtrophyParaplegiaRatsRats, WistarTOR Serine-Threonine KinasesmTOR protein, ratTOR Serine-Threonine KinasesExercise trainingMuscular atrophyNeurological rehabilitationProtein synthesisSpinal cord injuryTreadmill locomotor training

Identifiers

PMID29737479
OpenAlexW2802266123

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.