Evidence map›Paper›PMID 29737475›Full record

ArticleInflammation2018

Effect of a Stellate Ganglion Block on Acute Lung Injury in Septic Rats.

Yong Chen, Lian Guo, Haili Lang, Xiaolan Hu, Sun Jing, Mengsi Luo, Guohai Xu, Zhidong Zhou

Abstract read
PubMed Publisher
In one paragraph

Article in Inflammation, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 47 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Yong ChenDepartment of Anesthesiology, The Second Affiliated Hospital of Nanchang University, NO.1 Mingde Road, Nanchang, 330006, China.
Lian GuoDepartment of Anesthesiology, The Second Affiliated Hospital of Nanchang University, NO.1 Mingde Road, Nanchang, 330006, China.
Haili LangDepartment of Anesthesiology, The Second Affiliated Hospital of Nanchang University, NO.1 Mingde Road, Nanchang, 330006, China.
Xiaolan HuDepartment of Anesthesiology, The Second Affiliated Hospital of Nanchang University, NO.1 Mingde Road, Nanchang, 330006, China.
Sun JingDepartment of Anesthesiology, The Second Affiliated Hospital of Nanchang University, NO.1 Mingde Road, Nanchang, 330006, China.
Mengsi LuoDepartment of Anesthesiology, The Second Affiliated Hospital of Nanchang University, NO.1 Mingde Road, Nanchang, 330006, China.
Guohai XuDepartment of Anesthesiology, The Second Affiliated Hospital of Nanchang University, NO.1 Mingde Road, Nanchang, 330006, China.
Zhidong ZhouDepartment of Anesthesiology, The Second Affiliated Hospital of Nanchang University, NO.1 Mingde Road, Nanchang, 330006, China. zhidongzhou.2016@aliyun.com.
Second Affiliated Hospital of Nanchang University · CNNanchang University · CN

Funding

National Natural Science Foundation of China 81560193Science and Technology Research Project of Education Department of Jiangxi Province 150258the Young Fund of Science and Technology Plan of Second Affiliated Hospital of Nanchang University 2016YNQN12008
6 · The paper itself

Abstract

A stellate ganglion block (SGB) is a clinical sympathetic block which can inhibit the body systemic inflammatory response. However, whether and how SGB can attenuate the sepsis-induced acute lung injury remains unclear. Here, we evaluated the effect of SGB on sepsis-induced acute lung injury in rats. Ninety healthy Sprague Dawley (SD) male rats were divided into three groups: the sham operation group (S group), sepsis group (Sep group), and SGB group. The sepsis model rats were produced by cecum ligation and puncture (CLP), and blood samples were taken from the abdominal aorta of the rats at different time points for evaluating the concentration of TNF-α, IL-6, and IL-10 by enzyme-linked immunosorbent assay (ELISA). The rats were sacrificed, and lungs were collected to measure the wet/dry (W/D) lung tissue weight ratio, score the lung tissue pathological damage by microscopic examination, determine the myeloperoxidase (MPO) activity by spectrophotometry, and measure nuclear factor-kappa B (NF-κB) p65 expression by Western blot. The concentration of serum TNF-α, IL-6, and IL-10, lung tissue W/D ratio, pathological injury score, MPO activity, and expression of NF-κB p65 were higher in the Sep group compared with the S group at T

Indexed as

Acute Lung InjuryAnimalsBlood Specimen CollectionInterleukin-10Interleukin-6MalePeroxidaseRatsRats, Sprague-DawleySepsisStellate GanglionSympatholyticsTranscription Factor RelATreatment OutcomeTumor Necrosis Factor-alphaInterleukin-10Interleukin-6PeroxidaseRela protein, ratSympatholyticsTranscription Factor RelATumor Necrosis Factor-alphacecum ligation and puncture (CLP)ratsepsis-induced acute lung injurystellate ganglion nerve block (SGB)

Identifiers

PMID29737475
OpenAlexW2800709420

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.