Evidence map›Paper›PMID 29737458›Full record

ReviewStem cell reviews and reports2018

Dental Pulp Stem Cells - Exploration in a Novel Animal Model: the Tasmanian Devil (Sarcophilus harrisii).

Chelsea M Graham, Karlea L Kremer, Simon A Koblar, Monica A Hamilton-Bruce, Stephen B Pyecroft

Abstract readReview
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In one paragraph

Review in Stem cell reviews and reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 95% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Chelsea M GrahamSchool of Animal and Veterinary Sciences, Roseworthy campus, University of Adelaide, Roseworthy, South Australia, 5371, Australia. chelsea.graham@adelaide.edu.au.
Karlea L KremerStroke Research Programme, Discipline of Medicine, University of Adelaide, Adelaide, South Australia, 5000, Australia.
Simon A KoblarStroke Research Programme, Discipline of Medicine, University of Adelaide, Adelaide, South Australia, 5000, Australia.
Monica A Hamilton-BruceStroke Research Programme, Discipline of Medicine, University of Adelaide, Adelaide, South Australia, 5000, Australia.
Stephen B PyecroftSchool of Animal and Veterinary Sciences, Roseworthy campus, University of Adelaide, Roseworthy, South Australia, 5371, Australia.
University of Adelaide · AUCalvary Hospital · AU

Funding

Sir Mark Mitchell Research Foundation 61118100
6 · The paper itself

Abstract

Dental pulp stem cells (DPSC) are a heterogeneous population of highly proliferative stem cells located in the soft inner pulp tissue of the tooth. Demonstrated to have an affinity for neural differentiation, DPSC have been reported to generate functional Schwann cells (SC) through in vitro differentiation. Both DPSC and SC have neural crest origins, recently a significant population of DPSC have been reported to derive from peripheral nerve-associated glia. The predisposition DPSC have towards the SC lineage is not only a very useful tool for neural regenerative therapies in the medical field, it also holds great promise in the veterinary field. Devil Facial Tumour (DFT) is a clonally transmissible cancer of SC origin responsible for devastating wild populations of the Tasmanian devil. Very few studies have investigated the healthy Tasmanian devil SC (tdSC) for comparative studies between tdSC and DFT cells, and the development and isolation of a tdSC population is yet to be undertaken. A Tasmanian devil DPSC model offers a promising new outlook for DFT research, and the link between SC and DPSC may provide a potential explanation as to how a cancerous SC initially arose in a single Tasmanian devil to then go on to infect others as a parasitic clonal cell line. In this review we explore the current role of DPSC in human regenerative medicine, provide an overview of the Tasmanian devil and the devastating effect of DFT, and highlight the promising potential DPSC techniques pose for DFT research and our current understanding of DFT.

Indexed as

Cell DifferentiationAnimalsDental PulpFacial NeoplasmsHumansMarsupialiaNerve RegenerationRegenerative MedicineSchwann CellsStem CellsAnimal modelDasyuridaeDental pulp stem cellsDevil Facial TumourDifferentiationMarsupialNeural crestSchwann cellsTasmanian devil

Identifiers

PMID29737458
OpenAlexW2802337531

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.