ArticleMikrochimica acta2018
Colorimetric and energy transfer based fluorometric turn-on method for determination of microRNA using silver nanoclusters and gold nanoparticles.
Article in Mikrochimica acta, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Comprehensive Analysis of Advancement in Optical Biosensing Techniques for Early Detection of Cancerous Cells.Biosensors · 2025Review
- PCR Independent Strategy-Based Biosensors for RNA Detection.Biosensors · 2024Review
- Article
- "Plasmonic Nanomaterials": An emerging avenue in biomedical and biomedical engineering opportunities.Journal of advanced research · 2022Review
- Gold nanoparticle-based optical nanosensors for food and health safety monitoring: recent advances and future perspectives.RSC advances · 2022Review
- Sensitive detection of miRNA based on enzyme-propelled multiple photoinduced electron transfer strategy.Mikrochimica acta · 2021Article
- Nanotechnology in emerging liquid biopsy applications.Nano convergence · 2021Review
- SERS Based Lateral Flow Assay for Rapid and Ultrasensitive Quantification of Dual Laryngeal Squamous Cell Carcinoma-Related miRNA Biomarkers in Human Serum Using Pd-Au Core-Shell Nanorods and Catalytic Hairpin Assembly.Frontiers in molecular biosciences · 2021Article
- A novel quantification platform for point-of-care testing of circulating MicroRNAs based on allosteric spherical nanoprobe.Journal of nanobiotechnology · 2020Article
- Aptamer-based colorimetric determination of early-stage apoptotic cells via the release of cytochrome c from mitochondria and by exploiting silver/platinum alloy nanoclusters as a peroxidase mimic.Mikrochimica acta · 2019Article
- Fluorometric determination of microRNA using arched probe-mediated isothermal exponential amplification combined with DNA-templated silver nanoclusters.Mikrochimica acta · 2019Article
- Fluorometric determination of microRNA by using target-triggered cascade signal amplification and DNA-templated silver nanoclusters.Mikrochimica acta · 2019Article
- Ratiometric enhanced fluorometric determination and imaging of intracellular microRNA-155 by using carbon dots, gold nanoparticles and rhodamine B for signal amplification.Mikrochimica acta · 2019Article
- Biomedical applications of nanoflares: Targeted intracellular fluorescence probes.Nanomedicine : nanotechnology, biology, and medicine · 2019Review
- Detection of microRNA using a polydopamine mediated bimetallic SERS substrate and a re-circulated enzymatic amplification system.Mikrochimica acta · 2019Article
- A FRET-based dual-color evanescent wave optical fiber aptasensor for simultaneous fluorometric determination of aflatoxin M1 and ochratoxin A.Mikrochimica acta · 2018Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The authors describe a dual (colorimetric and fluorometric) detection scheme for microRNA. The method is based on the use of fluorescent DNA-modified silver nanoclusters (DNA-AgNCs) and gold nanoparticles (AuNPs). The DNA-AgNCs were linked to AuNPs via the interaction of ssDNA-AgNC probes with AuNPs. This led to quenching of the fluorescence of the DNA-AgNCs (best measured at excitation/emission peaks of 370/450 nm) and also prevents salt-induced aggregation of the AuNPs. Upon addition of microRNA, the DNA on the AgNCs hybridizes with microRNA. This led to the formation of a DNA-AgNC/miRNA hetero-duplex and increase of the distance to the AuNPs. Quenching was suppressed and fluorescence was restored. The presence of microRNA also affected salt-induced particle aggregation as reflected by a color change from red to purple that is visible with bare eyes. The visual detection limit for microRNA is 0.6 nM, and the fluorometric detection limit is 0.4 pM. Graphical abstract Schematic of the colorimetric and fluorometric assay for microRNA (miRNA). It is based on the use of fluorescent DNA-modified silver nanoclusters (AgNCs) and gold nanoparticles (AuNPs).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.