Evidence map›Paper›PMID 29737401›Full record

ArticleZeitschrift fur Rheumatologie2019

Transplantation of adipose tissue-derived stem cells ameliorates autoimmune pathogenesis in MRL/lpr mice : Modulation of the balance between Th17 and Treg.

W Zhang, Y-L Feng, C-Y Pang, F-A Lu, Y-F Wang

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Article in Zeitschrift fur Rheumatologie, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

W ZhangDepartment of Rheumatology and Immunology, First Hospital Affiliated to Baotou Medical College (Institution of Rheumatology and Immunology of BaoTou medical college), 31 Jianshe Road, 014040, Baotou, China.
Y-L FengDepartment of Ophthalmolo gy, First Hospital Affiliated to Baotou Medical College, 41 Linyin Road, 014010, Baotou, China.
C-Y PangDepartment of Rheumatology and Immunology, First Hospital Affiliated to Baotou Medical College (Institution of Rheumatology and Immunology of BaoTou medical college), 31 Jianshe Road, 014040, Baotou, China.
F-A LuDepartment of Rheumatology and Immunology, First Hospital Affiliated to Baotou Medical College (Institution of Rheumatology and Immunology of BaoTou medical college), 31 Jianshe Road, 014040, Baotou, China.
Y-F WangDepartment of Rheumatology and Immunology, First Hospital Affiliated to Baotou Medical College (Institution of Rheumatology and Immunology of BaoTou medical college), 31 Jianshe Road, 014040, Baotou, China. 18047211500@163.com.
Baotou Medical College · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMesenchymal stem cells (MSCs) are multipotent cells characterized by immunomodulatory properties and are therefore considered a promising tool for the treatment of autoimmune diseases. In this study, we aimed to investigate whether transplantation of adipose tissue-derived stem cells (ADSCs) affects the autoimmune pathogenesis in MRL/lpr mice.

methodsFifteen 12-week-old MRL/lpr mice were randomly divided into three groups: ADSC, cyclophosphamide (CTX), and control groups, with five mice in each group. ADSC and control groups were injected with 1 × 10

resultsEight weeks after treatment, the 24 h proteinuria, anti-dsDNA antibody levels, and serum creatinine were decreased significantly with transplantation of mouse ADSCs. ADSCs markedly reduced the number of TH17 cells, increased Treg cells, and improved renal pathology.

conclusionOur results indicate that transplantation of ADSCs could significantly inhibit autoimmune progression in MRL/lpr mice and the efficacy of ADSCs was comparable to that of CTX.

Indexed as

Lupus Erythematosus, SystemicTh17 CellsAdipose TissueAnimalsFemaleMiceMice, Inbred C57BLMice, Inbred MRL lprStem CellsT-Lymphocytes, RegulatoryAutoantibodiesAutoimmune diseasesCyclophosphamideLupus nephritisSystemic lupus erythematosus

Identifiers

PMID29737401
OpenAlexW2801472725

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.