Evidence map›Paper›PMID 29737194›Full record

ArticleAIDS research and human retroviruses2018

Characterization of Cellular Immune Responses in Thai Individuals With and Without HIV-Associated Neurocognitive Disorders.

Silvia Ratto-Kim, Alexandra Schuetz, Pasiri Sithinamsuwan, John Barber, Nicholas Hutchings, Sukalaya Lerdlum, James L K Fletcher, Yuwadee Phuang-Ngern, Weerawan Chuenarom, Somporn Tipsuk and 16 more

Abstract read
In one paragraph

Article in AIDS research and human retroviruses, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Trial
  5. Review
  6. Article
  7. Article
  8. Role of T Lymphocytes in HIV Neuropathogenesis.Current HIV/AIDS reports · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors.

Silvia Ratto-Kim1 U.S. Military HIV Research Program, Walter Reed Army Institute of Research , Silver Spring, Maryland.
Alexandra Schuetz1 U.S. Military HIV Research Program, Walter Reed Army Institute of Research , Silver Spring, Maryland.
Pasiri Sithinamsuwan4 Division of Neurology, Department of Medicine, Phramongkutklao Hospital , Bangkok, Thailand .
John Barber5 Clinical and Molecular Retrovirology Section/Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health , Bethesda, Maryland.
Nicholas Hutchings6 Columbia University College of Physicians and Surgeons , New York, New York.
Sukalaya Lerdlum7 Department of Radiology, Faculty of Medicine, Chulalongkorn University , Bangkok, Thailand .
James L K Fletcher8 SEARCH, Thai Red Cross AIDS Research Center , Bangkok, Thailand .
Yuwadee Phuang-Ngern3 Department of Retrovirology, Armed Forces Research Institute of Medical Sciences-United States Component , Bangkok, Thailand .
Weerawan Chuenarom3 Department of Retrovirology, Armed Forces Research Institute of Medical Sciences-United States Component , Bangkok, Thailand .
Somporn Tipsuk8 SEARCH, Thai Red Cross AIDS Research Center , Bangkok, Thailand .
Mantana Pothisri7 Department of Radiology, Faculty of Medicine, Chulalongkorn University , Bangkok, Thailand .
Tanate Jadwattanakul9 Department of Neurology, Washington University in St. Louis , St. Louis, Missouri.
Supunnee Jirajariyavej10 HIV Clinic, Taksin Hospital , Bangkok, Thailand .
Chayada Sajjaweerawan3 Department of Retrovirology, Armed Forces Research Institute of Medical Sciences-United States Component , Bangkok, Thailand .
Siriwat Akapirat3 Department of Retrovirology, Armed Forces Research Institute of Medical Sciences-United States Component , Bangkok, Thailand .
Thep Chalermchai8 SEARCH, Thai Red Cross AIDS Research Center , Bangkok, Thailand .
Duanghathai Suttichom8 SEARCH, Thai Red Cross AIDS Research Center , Bangkok, Thailand .
Boot Kaewboon3 Department of Retrovirology, Armed Forces Research Institute of Medical Sciences-United States Component , Bangkok, Thailand .
Peeriya Prueksakaew8 SEARCH, Thai Red Cross AIDS Research Center , Bangkok, Thailand .
Putthachard Karnsomlap8 SEARCH, Thai Red Cross AIDS Research Center , Bangkok, Thailand .
David Clifford11 Department of Psychology, University of Missouri , St. Louis, Missouri.
Robert H Paul11 Department of Psychology, University of Missouri , St. Louis, Missouri.
Mark S de Souza8 SEARCH, Thai Red Cross AIDS Research Center , Bangkok, Thailand .
Jerome H Kim12 International Vaccine Institute , Seoul, Korea.
Jintanat Ananworanich1 U.S. Military HIV Research Program, Walter Reed Army Institute of Research , Silver Spring, Maryland.
Victor Valcour13 Memory and Aging Center, Department of Neurology, University of California , San Francisco, California.

Funding

HIV-1 Specific Immune Responses in Thai Individuals with HIV DementiaR01NS053359 · NINDS · UNIVERSITY OF HAWAII AT MANOA · PI KIM, SILVIA R · 2007 to 2011
$1.6M
NINDS NIH HHS R01 NS053359
6 · The paper itself

Abstract

HIV-associated neurocognitive disorder (HAND) remains a challenge despite antiretroviral therapy (ART), and has been linked to monocyte/macrophage (M/M) migration to the brain. Due to the potential impact of T cell effector mechanisms in eliminating activated/HIV-infected M/M, T cell activation may play a role in the development of HAND. We sought to investigate the relationship between cognition and both CD8

Indexed as

Immunity, CellularLymphocyte ActivationAdultAIDS Dementia ComplexCD8-Positive T-LymphocytesFemaleHIV InfectionsHumansMaleMiddle AgedPlasmaThailandViral LoadYoung AdultCD8+ T cell activationHIV-associated neurocognitive disordersHIV-specific cytolytic T cells

Identifiers

PMID29737194
PMCPMC6080108

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.