Evidence map›Paper›PMID 29737021›Full record

ArticleStatistics in medicine2018

Functional interaction-based nonlinear models with application to multiplatform genomics data.

Clemontina A Davenport, Arnab Maity, Veerabhadran Baladandayuthapani

Abstract read
In one paragraph

Article in Statistics in medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Clemontina A DavenportDepartment of Biostatistics and Bioinformatics, Duke University Medical Center, Durham, NC, 27705, USA.ORCID 0000-0003-3875-7466
Arnab MaityDepartment of Statistics, North Carolina State University, Raleigh, NC, 27695, USA.
Veerabhadran BaladandayuthapaniDepartment of Biostatistics, University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.

Funding

Tumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Scott Kopetz · 1985 to 2026
$290.8M
Duke CTSA (Composite)UL1TR001117 · NCATS · DUKE UNIVERSITY · PI BOULWARE, LEIGH E, LI, JENNIFER S · 2013 to 2017
$41.3M
P4 -TARGETING MULTIPLE MYELOMA BY COMBINING CDK INHIBITORS AND BCL-2 ANTAGONISTSP50CA142509 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI KWAK, LARRY W · 2010 to 2014
$11.1M
Duke CTSA (Composite)KL2TR001115 · NCATS · DUKE UNIVERSITY · PI BOULWARE, LEIGH E, KRAFT, MONICA · 2013 to 2017
$5.1M
Graph-based Bayesian analysis of Genomics and Proteomics DataR01CA194391 · NCI · TEXAS A&M UNIVERSITY · PI BALADANDAYUTHAPANI, VEERABHADRAN, MALLICK, BANI K · 2016 to 2020
$2.0M
Integrative methods for high-dimensional genomics dataR01CA160736 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI BALADANDAYUTHAPANI, VEERABHADRAN · 2011 to 2014
$1.4M
Statistical Methods for Analysis of High-Dimensional Gene and Environment DataR00ES017744 · NIEHS · NORTH CAROLINA STATE UNIVERSITY RALEIGH · PI MAITY, ARNAB · 2011 to 2013
$663k
NCATS NIH HHS KL2 TR001115NCATS NIH HHS UL1 TR001117NCI NIH HHS P30 CA016672NCI NIH HHS P50 CA142509NCI NIH HHS R01 CA160736NCI NIH HHS R01 CA194391NIEHS NIH HHS R00 ES017744
6 · The paper itself

Abstract

Functional regression allows for a scalar response to be dependent on a functional predictor; however, not much work has been done when a scalar exposure that interacts with the functional covariate is introduced. In this paper, we present 2 functional regression models that account for this interaction and propose 2 novel estimation procedures for the parameters in these models. These estimation methods allow for a noisy and/or sparsely observed functional covariate and are easily extended to generalized exponential family responses. We compute standard errors of our estimators, which allows for further statistical inference and hypothesis testing. We compare the performance of the proposed estimators to each other and to one found in the literature via simulation and demonstrate our methods using a real data example.

Indexed as

Nonlinear DynamicsRegression AnalysisBiometryComputer SimulationGenomicsHumansbasis expansion approximationfunctional regressioninteracting covariatessemiparametric models

Identifiers

PMID29737021
PMCPMC6031473

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.