ArticleInternational journal for numerical methods in biomedical engineering2018
Simulation of actin distribution of osteoblasts on titanium pillar arrays using a bio-chemo-mechanical model.
Article in International journal for numerical methods in biomedical engineering, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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3 citing papers in PubMed, 7 citations in OpenAlex.
- Recent Advances on the Model, Measurement Technique, and Application of Single Cell Mechanics.International journal of molecular sciences · 2020Review
- Sub-Micropillar Spacing Modulates the Spatial Arrangement of Mouse MC3T3-E1 Osteoblastic Cells.Nanomaterials (Basel, Switzerland) · 2019Article
- Simulation of actin distribution of osteoblasts on titanium pillar arrays using a bio-chemo-mechanical model.International journal for numerical methods in biomedical engineering · 2018Article
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4 authors at 1 institution in 1 country.
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Abstract
A numerical model for the adhesion of osteoblasts on titanium micropillar structures is suggested, and a function representing the concentration level of the adhesion on the pillars is constructed based on experimental observation. The introduction of this function helps a well-known bio-chemo-mechanical model to better predict the formation of actin in osteoblasts when they are laid on arrays of titanium micro-pillars of various size attached to silicon substrate. A parameter study suggests that each pillar is associated with a different pattern of adhesion. Our finding emphasises a capability of the bio-chemo-mechanical model that it can well explain the strong influence of the boundary condition on the formation of actin within the cells.
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