Trial reportEuropean radiology2018
Towards volumetric thresholds in RECIST 1.1: Therapeutic response assessment in hepatic metastases.
Trial report in European radiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- AI-driven volumetric approach for automatic chemotherapy response assessment in colorectal liver metastases.European radiology · 2026Article
- Radiomic signatures from baseline CT predict chemotherapy response in unresectable colorectal liver metastases.Journal of medical imaging (Bellingham, Wash.) · 2026Article
- Relationship between spleen volume and diameter for assessment of response to treatment on CT in patients with hematologic malignancies enrolled in clinical trials.Abdominal radiology (New York) · 2025Article
- Comparing quantitative imaging biomarker alliance volumetric CT classifications with RECIST response categories.Radiology advances · 2025Article
- Article
- Improving assessment of lesions in longitudinal CT scans: a bi-institutional reader study on an AI-assisted registration and volumetric segmentation workflow.International journal of computer assisted radiology and surgery · 2024Article
- Article
- Follow-up of liver metastases: a comparison of deep learning and RECIST 1.1.European radiology · 2023Article
- RECIST 1.1 Target Lesion Categorical Response in Metastatic Renal Cell Carcinoma: A Comparison of Conventional versus Volumetric Assessment.Radiology. Imaging cancer · 2023Article
- Predictive power of deep-learning segmentation based prognostication model in non-small cell lung cancer.Frontiers in oncology · 2023Article
- The Potential and Emerging Role of Quantitative Imaging Biomarkers for Cancer Characterization.Cancers · 2022Review
- Assessment of immunotherapy response in intracranial malignancy using semi-automatic segmentation on magnetic resonance images.Frontiers in immunology · 2022Article
- How clinical imaging can assess cancer biology.Insights into imaging · 2019Review
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo empirically determine thresholds for volumetric assessment of response and progress of liver metastases in line with the unidimensional RECIST thresholds.
methodsPatients with metastatic colorectal cancer initially enrolled in a multicentre clinical phase-III trial were included. In all CT scans, the longest axial diameters and volumes of hepatic lesions were determined semi-automatically. The sum of diameters and volumes of 1, ≤2 and ≤5 metastases were compared to all previous examinations. Volumetric thresholds corresponding to RECIST 1.1 thresholds were predicted with loess-regression. In sensitivity analysis, the concordances of proposed thresholds, weight-maximizing thresholds and thresholds from loess-regression were compared. Classification concordance for measurements of ≤2 metastases was further analyzed.
resultsFor measurements of ≤2 metastases, 348 patients with 629 metastases were included, resulting in 4,773 value pairs. Regression analysis yielded volumetric thresholds of -65.3% for a diameter change of -30%, and +64.6% for a diameter change of +20%. When comparing measurements of unidimensional RECIST assessment with volumetric measurements, there was a concordance of significant progress (≥+20% and ≥+65%) in 88.3% and of significant response (≤-30% and ≤-65%) in 85.0%.
conclusionsIn patients with hepatic metastases, volumetric thresholds of +65% and -65% were yielded corresponding to RECIST thresholds of +20% and -30%. KEY POINTS: • Volumes and diameters of liver metastases from colorectal cancer were determined. • Volumetric thresholds of +65%/-65% corresponding to RECIST 1.1 are proposed. • Comparing both measurements, concordance was 88.3% (significant progress) and 85.0% (significant response).
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