Evidence map›Paper›PMID 29736668›Full record

ArticleJournal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract2018

Immunohistochemical Predictors for Intestinal and Pancreatobiliary Types of Adenocarcinoma of The Ampulla of Vater.

João Paulo Lemos da Silveira Santos, Carla Jorge Machado, Eduardo Paulino Junior, João Bernardo Sancio Rocha Rodrigues, Paula Teixeira Vidigal, Vivian Resende

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Article in Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

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5citing papers in PubMed
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1 · What the graph read from it

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3 · Its place in the literature

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5 citing papers in PubMed.

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5 · Who and what money

Authors and funding

6 authors.

João Paulo Lemos da Silveira SantosDepartment of Surgery, Medical School, UFMG, Belo Horizonte, Rua Sergipe, 67 apto 2401, Bairro Funcionários, Belo Horizonte, CEP 30130 170, Brazil.
Carla Jorge MachadoDepartment of Epidemiology, Medical School, UFMG, Belo Horizonte, Minas Gerais, Brazil.
Eduardo Paulino JuniorDepartment of Histopathology, Medical School, UFMG, Belo Horizonte, Minas Gerais, Brazil.
João Bernardo Sancio Rocha RodriguesDepartment of Surgery, Medical School, UFMG, Belo Horizonte, Rua Sergipe, 67 apto 2401, Bairro Funcionários, Belo Horizonte, CEP 30130 170, Brazil.
Paula Teixeira VidigalDepartment of Histopathology, Medical School, UFMG, Belo Horizonte, Minas Gerais, Brazil.
Vivian ResendeDepartment of Surgery, Medical School, UFMG, Belo Horizonte, Rua Sergipe, 67 apto 2401, Bairro Funcionários, Belo Horizonte, CEP 30130 170, Brazil. vivianresende.ufmg@gmail.com.ORCID 0000-0003-4400-0427

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo investigate immunohistochemical predictors for intestinal and pancreatobiliary types of adenocarcinoma of ampulla of Vater and identify clinicopathological characteristics associated with the histological types and patient survival.

methodsImmunohistochemical markers included MUC1, MUC2, MUC5AC, CDX2, CK7, and CK20. The data were analyzed by univariate and multivariate methods. The two-step cluster method was used to determine the best immunohistochemical markers to discriminate the intestinal from the pancreatobiliary type.

resultsThis study identified 9 (33.3%) intestinal and 21 (66.7%) pancreatobiliary tumors. CK7 and CDX2 achieved the highest value (= 1) as predictor markers, while CK20, MUC1, and MUC2 showed degrees of importance equal to 0.77, 0.71, and 0.68, respectively. MUC5AC did not reach 0.50 of importance. In the univariate analysis, lymph node involvement, staging (TNM), and angiolymphatic and perineural invasions were associated with histological types. The independent clinicopathological variable in the multivariate model to predict the histological type was angiolymphatic invasion (p = 0.005), OR = 17 (95% CI 2.33 to 123.83). The final model showed positive nodes (N1) associated with shorter survival (HR = 9.5; p = 0.006). Overall survival at 12, 36, and 60 months was 88.5, 67.0, and 47.6%, respectively.

conclusionsCDX2 and CK7 were the immunohistochemical markers that best discriminated the intestinal from the pancreatobiliary type. Lymph node involvement had a high impact on survival and proved to be more frequent in the pancreatobiliary type.

Indexed as

AdenocarcinomaAdultAgedAmpulla of VaterBile Duct NeoplasmsBile Ducts, IntrahepaticBiomarkers, TumorCDX2 Transcription FactorCommon Bile Duct NeoplasmsFemaleFollow-Up StudiesHumansImmunohistochemistryKeratinsMaleMiddle AgedBiomarkers, TumorCDX2 Transcription FactorKeratinsMucinsNeoplasm ProteinsAdenocarcinomaAmpulla of VaterImmunohistochemistrySurvival

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PMID29736668

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