ArticleEnvironmental science and pollution research international2018
Therapeutic effect of the alkaloid extract of the cyanobacterium Spirulina platensis on the lipid profile of hypercholesterolemic male rabbits.
Article in Environmental science and pollution research international, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04658875 (Effect of a Systematic Physical Exercise Program and Spirulina Maxima Supplementation on the Body Composition, Physical Function and Blood Lipid Profile in Sedentary Older Adults With Excess Weight), which is not on this map. Cited by 10 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effect of a Systematic Physical Exercise Program and Spirulina Maxima Supplementation on the Body Composition, Physical Function and Blood Lipid Profile in Sedentary Older Adults With Excess Weight
Who cites it
10 citing papers in PubMed, 36 citations in OpenAlex.
- Hypolipidemic Effect ofMarine drugs · 2019Trial
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- Antioxidant and antimicrobial activities ofSaudi journal of biological sciences · 2022Article
- Chlorella vulgaris or Spirulina platensis mitigate lead acetate-induced testicular oxidative stress and apoptosis with regard to androgen receptor expression in rats.Environmental science and pollution research international · 2021Article
- Impact ofInternational journal of environmental research and public health · 2021Article
- Systematic Physical Exercise andAntioxidants (Basel, Switzerland) · 2019Article
- Dose Effects of Orally AdministeredFrontiers in cellular and infection microbiology · 2019Article
- Effectiveness ofEvidence-based complementary and alternative medicine : eCAM · 2019Article
- Extract of Paecilomyces hepiali mycelia induces lipolysis through PKA-mediated phosphorylation of hormone-sensitive lipase and ERK-mediated downregulation of perilipin in 3T3-L1 adipocytes.BMC complementary and alternative medicine · 2018Article
- Quantifying the effects of spirulina supplementation on plasma lipid and glucose concentrations, body weight, and blood pressure.Diabetes, metabolic syndrome and obesity : targets and therapy · 2018Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 3 countries.
Funding
Abstract
The authors' objectives are to investigate the therapeutic effect of alkaloid extract of cyanobacteria Spirulina platensis on the lipid profile of hypercholesterolemic male rabbits and to identify the active compounds in the alkaloid extract. Male rabbits were divided into four groups of six animals. The intact rabbits in the first group served as a negative control. The second group served as a positive control (hypercholesterolemic rabbits). Over a 4-week period, hypercholesterolemic rabbits in the third group received a low dose of alkaloid extract (33 mg/kg), and the hypercholesterolemic rabbits in the fourth group received a high dose (66 mg/kg). The results revealed that both doses of alkaloid extract significantly decreased levels of cholesterol, triglycerides, low-density lipoproteins (LDL), and very low-density lipoproteins (VLDL) when compared to the control group, whereas the high-density lipoproteins (HDL) increased significantly compared to the control group. The active compounds in the alkaloid extract were identified using GC-mass. The most abundant compounds found in the extract were 1-(+)-ascorbic acid 2,6-dihexadecanoate, 9,12-octadecadienoic acid (Z, Z)-, hexadecanoic acid, 2-hydroxy-1- (hydroxymethyl) ethyl ester, and gamolenic acid.
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Registered trials
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