ReviewNeuroradiology2018
Leptomeningeal form of Immunoglobulin G4-related hypertrophic meningitis with perivascular spread: a case report and review of the literature.
Review in Neuroradiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
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Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.
- IgG4-Related Disease of the Skull and Skull Base-A Systematic Review and Report of Two Cases.World neurosurgery · 2021Pooled it
- Granulomatous Diseases of the CNS: Aetiology, Neuroradiological Features and Clinical Findings.Clinical neuroradiology · 2026Review
- Radiological insights into rheumatoid meningitis - a rare central nervous system manifestation of rheumatoid arthritis: a retrospective review of six cases.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024Article
- IgG4-related pachyleptomeningitis with inflammatory pseudotumor.eNeurologicalSci · 2024Article
- Recurrent myelitis and asymptomatic hypophysitis in IgG4-related disease: case-based review.Rheumatology international · 2020Review
- Hypertrophic Pachymeningitis in a Southern Chinese Population: A Retrospective Study.Frontiers in neurology · 2020Article
- Neuroradiological and clinical features in ophthalmoplegia.Neuroradiology · 2019Review
- Chronic Meningitis.Continuum (Minneapolis, Minn.) · 2018Review
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeImmunoglobulin G4 (IgG4)-related disease represents a spectrum of fibro-inflammatory disorders that affects various organ systems, including the central nervous system.
methodsHere we present the case of lgG4-related hypertrophic meningitis with exclusively leptomeningeal involvement and spread via perivascular spaces.
resultsA 58-year-old male patient presented with complex partial seizures. Initial computed tomography examination showed left frontal sulcal hyperdensity. Subsequent magnetic resonance examination revealed FLAIR hyperintensity in the central sulcus, with post-contrast enhancement in the form of "dotted line." Physical examination, routine laboratory, and cerebrospinal fluid analyses were unremarkable. Meningeal biopsy confirmed IgG4-related meningitis. After corticosteroid treatment, a complete resolution of imaging findings was observed. Two months later, the patient presented with relapsing neurological symptoms and radiological findings in postcentral, precentral, and temporal sulci, resembling the form of "dotted line" contrast enhancement. In addition, linear intraparenchymal enhancement that followed perivascular spaces was seen in the left parietal lobe. After repeated steroid therapy, all lesions resolved completely.
conclusionWe reported the first case of isolated IgG4-related leptomeningeal involvement with a "dotted line" enhancement and perivascular intraparenchymal spread. Although IgG4-related meningitis represents a rare disease, both clinicians and radiologists should include this condition in the differential diagnosis of unclear leptomeningeal disease.
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