ArticleJournal of industrial microbiology & biotechnology2018
Transcriptome remodeling of Pseudomonas putida KT2440 during mcl-PHAs synthesis: effect of different carbon sources and response to nitrogen stress.
Article in Journal of industrial microbiology & biotechnology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 32 citations in OpenAlex.
- Soybean nodulation shapes the rhizosphere microbiome to increase rapeseed yield.Journal of advanced research · 2025Article
- Physiology, fast and slow: bacterial response to variable resource stoichiometry and dilution rate.mSystems · 2024Article
- β-oxidation-polyhydroxyalkanoates synthesis relationship in Pseudomonas putida KT2440 revisited.Applied microbiology and biotechnology · 2023Article
- Recent trends of biotechnological production of polyhydroxyalkanoates from C1 carbon sources.Frontiers in bioengineering and biotechnology · 2022Review
- Sea-Ice BacteriaApplied and environmental microbiology · 2021Article
- Genome-wide gene expression changes of Pseudomonas veronii 1YdBTEX2 during bioaugmentation in polluted soils.Environmental microbiome · 2021Article
- The Hypoxia-Associated Localization of Chemotaxis Protein CheZ inFrontiers in microbiology · 2021Article
- Transcriptome Changes inInternational journal of molecular sciences · 2020Article
- Genome-scale metabolic rewiring improves titers rates and yields of the non-native product indigoidine at scale.Nature communications · 2020Article
- Industrial biotechnology of Pseudomonas putida: advances and prospects.Applied microbiology and biotechnology · 2020Review
- Pseudomonas putida KT2440 is naturally endowed to withstand industrial-scale stress conditions.Microbial biotechnology · 2020Article
- Proteomic Response ofBiomolecules · 2019Article
- A 2D-DIGE-based proteomic analysis brings new insights into cellular responses of Pseudomonas putida KT2440 during polyhydroxyalkanoates synthesis.Microbial cell factories · 2019Article
- Time-Course Proteomic Analysis ofPolymers · 2019Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Bacterial response to environmental stimuli is essential for survival. In response to fluctuating environmental conditions, the physiological status of bacteria can change due to the actions of transcriptional regulatory machinery. The synthesis and accumulation of polyhydroxyalkanoates (PHAs) are one of the survival strategies in harsh environments. In this study, we used transcriptome analysis of Pseudomonas putida KT2440 to gain a genome-wide view of the mechanisms of environmental-friendly biopolymers accumulation under nitrogen-limiting conditions during conversion of metabolically different carbon sources (sodium gluconate and oleic acid). Transcriptomic data revealed that phaG expression is associated with medium-chain-length-PHAs' synthesis not only on sodium gluconate but also on oleic acid, suggesting that PhaG may play a role in this process, as well. Moreover, genes involved in the β-oxidation pathway were induced in the PHAs production phase when sodium gluconate was supplied as the only carbon and energy source. The transition from exponential growth to stationary phase caused a significant expression of genes involved in nitrogen metabolism, energy supply, and transport system. In this study, several molecular mechanisms, which drive mcl-PHAs synthesis, have been investigated. The identified genes may provide valuable information to improve the efficiency of this bioprocess and make it more economically feasible.
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Registered trials
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