Evidence map›Paper›PMID 29736598›Full record

ArticleJournal of the American Society for Mass Spectrometry2018

Photodissociative Cross-Linking of Non-covalent Peptide-Peptide Ion Complexes in the Gas Phase.

Huong T H Nguyen, Prokopis C Andrikopoulos, Lubomír Rulíšek, Christopher J Shaffer, František Tureček

Abstract read
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In one paragraph

Article in Journal of the American Society for Mass Spectrometry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Huong T H NguyenDepartment of Chemistry, Bagley Hall, University of Washington, Box 351700, Seattle, WA, 98195-1700, USA.
Prokopis C AndrikopoulosInstitute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Flemingovo nám. 2, 166 10, Prague, Czech Republic.
Lubomír RulíšekInstitute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Flemingovo nám. 2, 166 10, Prague, Czech Republic.
Christopher J ShafferDepartment of Chemistry, Bagley Hall, University of Washington, Box 351700, Seattle, WA, 98195-1700, USA.
František TurečekDepartment of Chemistry, Bagley Hall, University of Washington, Box 351700, Seattle, WA, 98195-1700, USA. turecek@chem.washington.edu.ORCID http://orcid.org/0000-0001-7321-7858

Funding

Division of Chemistry CHE-1661815
6 · The paper itself

Abstract

We report a gas-phase UV photodissociation study investigating non-covalent interactions between neutral hydrophobic pentapeptides and peptide ions incorporating a diazirine-tagged photoleucine residue. Phenylalanine (Phe) and proline (Pro) were chosen as the conformation-affecting residues that were incorporated into a small library of neutral pentapeptides. Gas-phase ion-molecule complexes of these peptides with photo-labeled pentapeptides were subjected to photodissociation. Selective photocleavage of the diazirine ring at 355 nm formed short-lived carbene intermediates that underwent cross-linking by insertion into H-X bonds of the target peptide. The cross-link positions were established from collision-induced dissociation tandem mass spectra (CID-MS

Indexed as

Born-Oppenheimer molecular dynamicsCross-linkingDiazirine tagsPeptide-peptide complexesPhotodissociation

Identifiers

PMID29736598

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.