Evidence map›Paper›PMID 29736561›Full record

ArticleMolecular imaging and biology2018

The Utility of [

Corinne Beinat, Tom Haywood, Yun-Sheng Chen, Chirag B Patel, Israt S Alam, Surya Murty, Sanjiv Sam Gambhir

Abstract readEvaluation Study
PubMed Publisher
In one paragraph

Article in Molecular imaging and biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.6field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 14 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. A Clinical PET Imaging Tracer ([Clinical cancer research : an official journal of the American Association for Cancer Research · 2021
    Article
  6. Article
  7. Human biodistribution and radiation dosimetry of [European journal of nuclear medicine and molecular imaging · 2020
    Article
  8. The Characterization ofJournal of nuclear medicine : official publication, Society of Nuclear Medicine · 2019
    Article
  9. Molecular Imaging with Reporter Genes: Has Its Promise Been Delivered?Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2019
    Review
  10. Positron emission tomography reporter gene strategy for use in the central nervous system.Proceedings of the National Academy of Sciences of the United States of America · 2019
    Article
  11. Development of [Nuclear medicine and biology
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Corinne BeinatDepartment of Radiology, Molecular Imaging Program at Stanford, Stanford University School of Medicine, Stanford, CA, 943065, USA.
Tom HaywoodDepartment of Radiology, Molecular Imaging Program at Stanford, Stanford University School of Medicine, Stanford, CA, 943065, USA.
Yun-Sheng ChenDepartment of Radiology, Molecular Imaging Program at Stanford, Stanford University School of Medicine, Stanford, CA, 943065, USA.
Chirag B PatelDepartment of Radiology, Molecular Imaging Program at Stanford, Stanford University School of Medicine, Stanford, CA, 943065, USA.
Israt S AlamDepartment of Radiology, Molecular Imaging Program at Stanford, Stanford University School of Medicine, Stanford, CA, 943065, USA.
Surya MurtyDepartment of Radiology, Molecular Imaging Program at Stanford, Stanford University School of Medicine, Stanford, CA, 943065, USA.
Sanjiv Sam GambhirDepartment of Radiology, Molecular Imaging Program at Stanford, Stanford University School of Medicine, Stanford, CA, 943065, USA. sgambhir@stanford.edu.
Stanford University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThere is a strong, unmet need for superior positron emission tomography (PET) imaging agents that are able to measure biochemical processes specific to prostate cancer. Pyruvate kinase M2 (PKM2) catalyzes the concluding step in glycolysis and is a key regulator of tumor growth and metabolism. Elevation of PKM2 expression was detected in Gleason 8-10 tumors compared to Gleason 6-7 carcinomas, indicating that PKM2 may potentially be a marker of aggressive prostate cancer. We have recently reported the development of a PKM2-specific radiopharmaceutical [ PROCEDURE: The cellular uptake of [

results[

conclusionHerein, we evaluated a F-18-labeled PKM2-specific radiotracer, [

Indexed as

AnimalsCell Line, TumorDiazonium CompoundsFluorodeoxyglucose F18GlycolysisHeterograftsHumansMaleMiceMice, NudeMolecular ImagingNeoplasm TransplantationPC-3 CellsPositron-Emission TomographyPredictive Value of TestsProstatic Neoplasmsdiazobenzenesulfonic acidDiazonium CompoundsFluorodeoxyglucose F18Sulfanilic Acids[18F]DASA-23Positron emission tomographyProstate cancerPyruvate kinase M2Tumor glycolysis

Identifiers

PMID29736561
OpenAlexW2801389784

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.