ArticleCurrent opinion in toxicology2018
Aggregate Exposure Pathways in Support of Risk Assessment.
Article in Current opinion in toxicology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Organizing mechanism-related information on chemical interactions using a framework based on the aggregate exposure and adverse outcome pathways.Environment international · 2020Pooled it
- Rewriting paracelsus: linking chemical assessment to public health.Frontiers in toxicology · 2026Review
- Adopting Mechanistic Molecular Biology Approaches in Exposome Research for Causal Understanding.Environmental science & technology · 2024Review
- Application of AOPs to assist regulatory assessment of chemical risks - Case studies, needs and recommendations.Environmental research · 2023Review
- Evidence integration on health damage for humidifier disinfectant exposure and legal presumption of causation.Epidemiology and health · 2023Article
- Neurotoxicity of diesel exhaust extracts in zebrafish and its implications for neurodegenerative disease.Scientific reports · 2022Article
- Article
- Evolving Science and Practice of Risk Assessment.Risk analysis : an official publication of the Society for Risk Analysis · 2021Article
- Quantification of an Adverse Outcome Pathway Network by Bayesian Regression and Bayesian Network Modeling.Integrated environmental assessment and management · 2021Article
- Application of a combined aggregate exposure pathway and adverse outcome pathway (AEP-AOP) approach to inform a cumulative risk assessment: A case study with phthalates.Toxicology in vitro : an international journal published in association with BIBRA · 2020Article
- Studying the Pathophysiology of Parkinson's Disease Using Zebrafish.Biomedicines · 2020Review
- Exposure to New Emerging Bisphenols Among Young Children in Switzerland.International journal of environmental research and public health · 2020Article
- Diesel Exhaust Extract Exposure Induces Neuronal Toxicity by Disrupting Autophagy.Toxicological sciences : an official journal of the Society of Toxicology · 2020Article
- A Quantitative Source-to-Outcome Case Study To Demonstrate the Integration of Human Health and Ecological End Points Using the Aggregate Exposure Pathway and Adverse Outcome Pathway Frameworks.Environmental science & technology · 2019Article
- Public data sources to support systems toxicology applications.Current opinion in toxicology · 2019Article
- A proposal for creating a taxonomy of chemical interactions using concepts from the aggregate exposure and adverse outcome pathways.Current opinion in toxicology · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
Over time, risk assessment has shifted from establishing relationships between exposure to a single chemical and a resulting adverse health outcome, to evaluation of multiple chemicals and disease outcomes simultaneously. As a result, there is an increasing need to better understand the complex mechanisms that influence risk of chemical and non-chemical stressors, beginning at their source and ending at a biological endpoint relevant to human or ecosystem health risk assessment. Just as the Adverse Outcome Pathway (AOP) framework has emerged as a means of providing insight into mechanism-based toxicity, the exposure science community has seen the recent introduction of the Aggregate Exposure Pathway (AEP) framework. AEPs aid in making exposure data applicable to the FAIR (i.e., findable, accessible, interoperable, and reusable) principle, especially by (1) organizing continuous flow of disjointed exposure information;(2) identifying data gaps, to focus resources on acquiring the most relevant data; (3) optimizing use and repurposing of existing exposure data; and (4) facilitating interoperability among predictive models. Herein, we discuss integration of the AOP and AEP frameworks and how such integration can improve confidence in both traditional and cumulative risk assessment approaches.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.