ArticleContemporary clinical trials communications2016
Factors affecting patient participation in clinical trials in Ireland: A narrative review.
Article in Contemporary clinical trials communications, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
53 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Recruitment rates and strategies in exercise trials in cancer survivorship: a systematic review.Journal of cancer survivorship : research and practice · 2024Pooled it
- Trial
- Motivation to Consent and Adhere to the FORT Randomized Controlled Trial.Current oncology (Toronto, Ont.) · 2022Trial
- Trial
- A pilot feasibility randomised clinical trial comparing dialkylcarbamoylchloride-coated dressings versus standard care for the primary prevention of surgical site infection.International wound journal · 2019Trial
- Awareness and willingness to participate in drug clinical trials among college students: a cross-sectional study in China.BMC public health · 2026Article
- Article
- Attitudes and Willingness to Participate in Drug Clinical Trials Among Patients With Cancer: Multistage Qualitative Study.Journal of medical Internet research · 2026Article
- Factors Associated with Willingness to Participate in Clinical Trials in Poles: A Cross-Sectional Prospective Study.Journal of clinical medicine · 2026Article
- Vietnamese University Students' Perceptions and Attitudes Toward Participation in Clinical Research: Mixed Methods Study.Journal of participatory medicine · 2026Article
- Awareness, Willingness, and Concerns about Clinical Trial Participation among Iraqi Patients: A Cross-Sectional Study.Global heart · 2026Article
- Survey of willingness to participate in clinical trials and influencing factors among cancer and non-cancer patients.Scientific reports · 2025Article
- Strategies to build trust in the conduct of clinical trials: Stakeholders' views in a qualitative study in Ghana.PLOS global public health · 2025Article
- Recruitment and retention in young adult health research: Motivations and barriers.Journal of clinical and translational science · 2025Article
- Knowledge and perception of a clinical trial among the participants: An experience from oral cholera vaccine study in Koshi Province, Nepal.Human vaccines & immunotherapeutics · 2024Article
- What motivates people with type 2 diabetes mellitus to participate in clinical trials from home?Clinical and translational science · 2024Article
- Patient Enrollment per Month (Accrual) in Clinical Trials Leading to the FDA Approval of New Cancer Drugs.Targeted oncology · 2024Article
- Primary care patient interests in joining a planned multi-cancer early detection clinical trial.Cancer medicine · 2024Article
- Regional disparities in the availability of cancer clinical trials in Korea.Epidemiology and health · 2024Article
- Exploring the Decision-Making Process of People Living with HIV Enrolled in Antiretroviral Clinical Trials: A Qualitative Study of Decisions Guided by Trust and Emotions.Health care analysis : HCA : journal of health philosophy and policy · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveClinical trials have long been considered the 'gold standard' of research generated evidence in health care. Patient recruitment is an important determinant in the success of the trials, yet little focus is placed on the decision making process of patients towards recruitment. Our objective was to identify the key factors pertaining to patient participation in clinical trials, to better understand the identified low participation rate of patients in one clinical research facility within Ireland.
designNarrative literature review of studies focussing on factors which may act to facilitate or deter patient participation in clinical trials. Studies were identified from Medline, PubMed, Cochrane Library and CINAHL.
resultsSixty-one studies were included in the narrative review: Forty-eight of these papers focused specifically on the patient's perspective of participating in clinical trials. The remaining thirteen related to carers, family and health care professional perspectives of participation. The primary factor influencing participation in clinical trials amongst patients was related to personal factors and these were collectively associated with obtaining a form of personal gain through participation. Cancer was identified as the leading disease entity included in clinical trials followed by HIV and cardiovascular disease.
conclusionThe vast majority of literature relating to participation in clinical trials emanates predominantly from high income countries, with 63% originating from the USA. No studies for inclusion in this review were identified from low income or developing countries and therefore limits the generalizability of the influencing factors.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.