ArticleTranslational vision science & technology2018
Thermal Stimulation of the Retina Reduces Bruch's Membrane Thickness in Age Related Macular Degeneration Mouse Models.
Article in Translational vision science & technology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 41 citations in OpenAlex.
- Generation of dual mouse models of retinal degeneration with slow and rapid progression driven by ectopic RIP3 expression.PloS one · 2026Article
- Nanosecond laser induces proliferation and improved cellular health within the retinal pigment epithelium.Frontiers in medicine · 2025Article
- Effects of Fucoidans on Activated Retinal Microglia.International journal of molecular sciences · 2024Article
- Diverse functions and pathogenetic role of Crumbs in retinopathy.Cell communication and signaling : CCS · 2024Review
- Article
- Real-Time Temperature-Controlled Retinal Laser Irradiation in Rabbits.Translational vision science & technology · 2024Article
- Optical Coherence Tomography: Imaging Visual System Structures in Mice.Methods in molecular biology (Clifton, N.J.) · 2023Article
- Implications of Neural Plasticity in Retinal Prosthesis.Investigative ophthalmology & visual science · 2022Article
- Temperature Increase and Damage Extent at Retinal Pigment Epithelium Compared between Continuous Wave and Micropulse Laser Application.Life (Basel, Switzerland) · 2022Article
- Properties of Cephalopod Skin Ommochromes to Inhibit Free Radicals, and the Maillard Reaction and Retino-Protective Mechanisms in Cellular Models Concerning Oxidative Stress, Angiogenesis, and Inflammation.Antioxidants (Basel, Switzerland) · 2022Article
- Selective retina therapy and thermal stimulation of the retina: different regenerative properties - implications for AMD therapy.BMC ophthalmology · 2021Article
- Retinal Pigment Epithelium Expressed Toll-like Receptors and Their Potential Role in Age-Related Macular Degeneration.International journal of molecular sciences · 2021Review
- Influence of Retinal Microsecond Pulse Laser Treatment in Central Serous Chorioretinopathy: A Short-Term Optical Coherence Tomography Angiography Study.Journal of clinical medicine · 2021Article
- Fucoidans as Potential Therapeutics for Age-Related Macular Degeneration-Current Evidence from In Vitro Research.International journal of molecular sciences · 2020Review
- Retbindin: A riboflavin Binding Protein, Is Critical for Photoreceptor Homeostasis and Survival in Models of Retinal Degeneration.International journal of molecular sciences · 2020Article
- Modulation of inflammatory processes by thermal stimulating and RPE regenerative laser therapies in age related macular degeneration mouse models.Cytokine: X · 2020Article
- Novel Porcine Retina Cultivation Techniques Provide Improved Photoreceptor Preservation.Frontiers in neuroscience · 2020Article
- Organ Cultures for Retinal Diseases.Frontiers in neuroscience · 2020Review
- Selective Retina Therapy Reduces Bruch's Membrane Thickness and Retinal Pigment Epithelium Pathology in Age-Related Macular Degeneration Mouse Models.Translational vision science & technology · 2019Article
- En-Face Optical Coherence Tomography Angiography for Longitudinal Monitoring of Retinal Injury.Applied sciences (Basel, Switzerland) · 2019Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo investigate the effect of thermal stimulation of the retina (TS-R) on Bruch's membrane (BrM) thickness in age-related macular degeneration (AMD) mouse models as a novel concept for the prophylaxis and treatment of dry AMD.
methodsTwo knockout AMD mouse models, B6.129P2-Apoe
resultsFundus images revealed that all ApoE-/- and NRF2-/- mice had AMD associated retinal alterations. BrM thickness was increased in untreated controls of both mouse models. Subvisible TS-R laser spots were not detectable by fundus imaging, OCT, or FLA 2 hours or 1 month after laser treatment. TEM revealed a significant reduction of BrM thickness in laser-treated eyes of all four groups compared to their fellow control eyes.
conclusionsTS-R reduces BrM thickness in AMD mouse models ApoE-/- and NRF2-/- without damage to the neuroretina. It may become a prophylactic or even therapeutic treatment option for dry AMD. TRANSLATIONAL RELEVANCE: TS-R may become a prophylactic or even therapeutic treatment option for dry AMD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.