Evidence map›Paper›PMID 29736270›Full record

ArticleNPJ vaccines2018

FIV vaccine with receptor epitopes results in neutralizing antibodies but does not confer resistance to challenge.

Craig Miller, Mauren Emanuelli, Elizabeth Fink, Esther Musselman, Ryan Mackie, Ryan Troyer, John Elder, Sue VandeWoude

Open access · goldAbstract read
In one paragraph

Article in NPJ vaccines, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.7field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Craig Miller1Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, CO USA.ORCID 0000-0002-3638-5665
Mauren Emanuelli1Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, CO USA.
Elizabeth Fink2Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA USA.
Esther Musselman1Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, CO USA.
Ryan Mackie1Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, CO USA.
Ryan Troyer1Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, CO USA.
John Elder2Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA USA.
Sue VandeWoude1Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, CO USA.
Colorado State University · USScripps Research Institute · US

Funding

MOLECULAR CHARACTERIZATION OF FIVR01AI025825 · NIAID · SCRIPPS RESEARCH INSTITUTE, THE · PI ELDER, JOHN H · 1987 to 2015
$6.0M
NIAID NIH HHS R01 AI025825
6 · The paper itself

Abstract

Feline immunodeficiency virus (FIV) is the feline analogue to human immunodeficiency virus (HIV) and utilizes parallel modes of receptor-mediated entry. The FIV surface glycoprotein (SU) is an important target for induction of neutralizing antibodies, and autoantibodies to the FIV binding receptor (CD134) block infection ex vivo; thus highlighting the potential for immunotherapies which utilize anti-receptor antibodies to block viral infection. To determine whether vaccination with CD134-SU complexes could induce protection against FIV infection, cats (

Identifiers

PMID29736270
PMCPMC5928050
OpenAlexW2805746536

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.