Evidence map›Paper›PMID 29736244›Full record

ArticlePharmacology research & perspectives2018

Propranolol pharmacokinetics in infants treated for Infantile Hemangiomas requiring systemic therapy: Modeling and dosing regimen recommendations.

Laurence Del Frari, Christine Léauté-Labrèze, Laurent Guibaud, Sébastien Barbarot, Jean-Philippe Lacour, Christine Chaumont, Alain Delarue, Jean-Jacques Voisard, Valérie Brunner

Abstract readMulticenter Study
In one paragraph

Article in Pharmacology research & perspectives, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Critical role of Aquaporin-1 and telocytes in infantile hemangioma response to propranolol beta blockade.Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Laurence Del FrariPKPD Department Pierre Fabre Médicament Toulouse France.ORCID 0000-0001-8957-8826
Christine Léauté-LabrèzeUnité de Dermatologie Pédiatrique Hôpital Pellegrin-Enfants Bordeaux France.
Laurent GuibaudConsultation des angiomes Imagerie pédiatrique et fœtale Hôpital Mère -Enfant Lyon France.
Sébastien BarbarotDépartement Dermatologie Hôtel-Dieu Nantes France.
Jean-Philippe LacourDépartement Dermatologie Hôpital L'Archet Nice France.
Christine ChaumontDevelopment Department Pierre Fabre Dermatologie Toulouse France.
Alain DelarueMedical Department Pierre Fabre Dermatologie Toulouse France.
Jean-Jacques VoisardPierre Fabre Dermatologie Toulouse France.
Valérie BrunnerSERVIER Laboratories Center of Excellence Pharmacokinetics Suresnes France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Propranolol has become the first choice therapy for complicated Infantile Hemangiomas (IH). The pharmacokinetics of propranolol were evaluated after repeated oral administration of a new pediatric solution of propranolol at 3 mg kg

Indexed as

Administration, OralAdrenergic beta-AntagonistsBody WeightDrug Administration ScheduleDrug Dosage CalculationsFemaleHemangiomaHumansInfantMaleModels, TheoreticalMonte Carlo MethodPractice Guidelines as TopicPropranololAdrenergic beta-AntagonistsPropranololPharmacokinetic Population analysis Modeling and Simulation Dermatology Pediatrics

Identifiers

PMID29736244
PMCPMC5925426

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.