Evidence map›Paper›PMID 29736233›Full record

ArticleCell & bioscience2018

NOS2 deficiency has no influence on the radiosensitivity of the hematopoietic system.

Chengcheng Li, Yi Luo, Lijian Shao, Aimin Meng, Daohong Zhou

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell & bioscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 92% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Chengcheng Li *1Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences (CAMS) and Comparative Medicine Center, Peking Union Medical College (PUMC), Key Laboratory of Human Disease Comparative Medicine, Ministry of Health, Beijing Key Laboratory for Animal Models of Emerging and Remerging Infectious Diseases, Beijing, 100021 China.
Yi Luo *2Department of Pharmaceutical Sciences, University of Arkansas for Medical Sciences, Little Rock, AR USA.
Lijian Shao2Department of Pharmaceutical Sciences, University of Arkansas for Medical Sciences, Little Rock, AR USA.
Aimin Meng1Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences (CAMS) and Comparative Medicine Center, Peking Union Medical College (PUMC), Key Laboratory of Human Disease Comparative Medicine, Ministry of Health, Beijing Key Laboratory for Animal Models of Emerging and Remerging Infectious Diseases, Beijing, 100021 China.
Daohong Zhou2Department of Pharmaceutical Sciences, University of Arkansas for Medical Sciences, Little Rock, AR USA.
University of Arkansas for Medical Sciences · USChinese Academy of Medical Sciences & Peking Union Medical College · CN

Funding

Cancer Therapy-induced Long-term Bone Marrow InjuryR01CA122023 · NCI · UNIV OF ARKANSAS FOR MED SCIS · PI ZHOU, DAOHONG · 2007 to 2018
$3.1M
Role of p38 MAPK in HSC Self-Renewal and Radiation-Induced Bone Marrow InjuryR01AI080421 · NIAID · UNIV OF ARKANSAS FOR MED SCIS · PI ZHOU, DAOHONG · 2008 to 2012
$1.8M
NCI NIH HHS R01 CA122023NIAID NIH HHS R01 AI080421
6 · The paper itself

Abstract

objectivePrevious studies have shown that inhibition of inducible NO synthase (NOS2 or iNOS) with an inhibitor can selectively protect several normal tissues against radiation during radiotherapy. However, the role of NOS2 in ionizing radiation (IR)-induced bone marrow (BM) suppression is unknown and thus was investigated in the present study using NOS2

methodsThe effects of different doses of IR (1, 2 and 4 Gy) on the apoptosis and colony-forming ability of bone marrow cells from wild-type (WT) and NOS2

resultsExposure to 2 and 4 Gy IR induced bone marrow cell apoptosis and inhibited the proliferation of HPCs in vitro. However, there was no difference between the cells from WT mice and NOS2

conclusionThese data suggest that IR induces BM suppression in a NOS2-independent manner.

Indexed as

Hematopoietic stem cellIonizing radiationNOS2−/−

Identifiers

PMID29736233
PMCPMC5922011
OpenAlexW2806347837

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.