Evidence map›Paper›PMID 29736214›Full record

ArticleAmerican journal of translational research2018

Masquelet's induced membrane promotes the osteogenic differentiation of bone marrow mesenchymal stem cells by activating the Smad and MAPK pathways.

Qian Tang, Minji Tong, Gang Zheng, Liyan Shen, Ping Shang, Haixiao Liu

Open access · greenAbstract read
In one paragraph

Article in American journal of translational research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.

  1. Pooled it
  2. Mechanisms of the Masquelet technique to promote bone defect repair and its influencing factors.Chinese journal of traumatology = Zhonghua chuang shang za zhi · 2025
    Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Is the bioactivity of induced membranes time dependent?European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2022
    Article
  10. The induced membrane technique in animal models: a systematic review.OTA international : the open access journal of orthopaedic trauma · 2022
    Article
  11. Article
  12. Article
  13. Masquelet's induced membrane technique: Review of current concepts and future directions.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2021
    Review
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Qian TangDepartment of Orthopaedic Surgery, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University 109, Xueyuanxi Road, Wenzhou 325027, China.
Minji TongDepartment of Orthopaedic Surgery, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University 109, Xueyuanxi Road, Wenzhou 325027, China.
Gang ZhengDepartment of Orthopaedic Surgery, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University 109, Xueyuanxi Road, Wenzhou 325027, China.
Liyan ShenDepartment of Orthopaedic Surgery, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University 109, Xueyuanxi Road, Wenzhou 325027, China.
Ping ShangDepartment of Rehabilitation, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University 109, Xueyuanxi Road, Wenzhou 325027, China.
Haixiao LiuDepartment of Orthopaedic Surgery, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University 109, Xueyuanxi Road, Wenzhou 325027, China.
Wenzhou Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The Masquelet's induced membrane (IM) technique is widely used to treat large segmental bone defects due to its physical priority and biological function. However, the underlying molecular mechanism of the IM on bone formation remains unknown. In the present study, rat bone marrow-derived mesenchymal stem cells (BMSCs) were used as an

Indexed as

induced membraneMAPKMasqueletosteogenesisSmad

Identifiers

PMID29736214
PMCPMC5934580
OpenAlexW2981806690

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.