ArticleAmerican journal of translational research2018
Effects of AAV2-mediated co-transfection of CTGF and TIMP1 genes on degenerative lumbar intervertebral discs in rhesus monkeys in vivo.
Article in American journal of translational research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
5 citing papers in PubMed, 9 citations in OpenAlex.
- Article
- A potential target gene CD63 for different degrees of intervertebral disc degeneration.Scientific reports · 2022Article
- Animal models of regenerative medicine for biological treatment approaches of degenerative disc diseases.Experimental biology and medicine (Maywood, N.J.) · 2021Review
- Analysis of key genes and pathways associated with the pathogenesis of intervertebral disc degeneration.Journal of orthopaedic surgery and research · 2020Article
- The research of transgenic human nucleus pulposus cell transplantation in the treatment of lumbar disc degeneration.The Kaohsiung journal of medical sciences · 2019Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThis study aims to investigate the effects of co-transfection of the genes for connective tissue growth factor (CTGF) and tissue inhibitor of metalloproteinase-1 (TIMP1) mediated by adeno-associated virus 2 (AAV2) on degenerative lumbar intervertebral discs in a primate model.
methodsTwelve 4-7 year-old rhesus monkeys weighing 4.5-7.0 kg were utilized.
resultsAt post-transfection, CTGF mRNA expression was higher in the transfection group than in the control group (
conclusionThe stable expression of
Indexed as
Identifiers
29736202PMC5934568W2980131860What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.