ArticleEuropean journal of mechanics. B, Fluids
Experimental Investigation of the Effect of Non-Newtonian Behavior of Blood Flow in the Fontan Circulation.
Article in European journal of mechanics. B, Fluids. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Non-Newtonian Effects on Patient-Specific Modeling of Fontan Hemodynamics.Annals of biomedical engineering · 2020Trial
- Significance of Reynolds Number Consistency in Non-Newtonian Hemodynamic Simulations: Insights from Fontan Circulation.Physics of fluids (Woodbury, N.Y. : 1994) · 2025Article
- Biomechanics and clinical implications of Fontan upsizing.Computers in biology and medicine · 2024Article
- The impact of blood viscosity modeling on computational fluid dynamic simulations of pediatric patients with Fontan circulation.Physics of fluids (Woodbury, N.Y. : 1994) · 2024Article
- Biomechanical Analysis of Age-Dependent Changes in Fontan Power Loss.Annals of biomedical engineering · 2024Article
- Decreased erythrocyte aggregation in Glenn and Fontan: univentricular circulation as a rheologic disease model.Pediatric research · 2024Article
- In vitro hemodynamic performance of a blood pump for self-powered venous assist in univentricular hearts.Scientific reports · 2024Article
- Article
- In Silico Evaluation of a Self-powered Venous Ejector Pump for Fontan Patients.Cardiovascular engineering and technology · 2023Article
- Hemodynamic characteristics in a cerebral aneurysm model using non-Newtonian blood analogues.Physics of fluids (Woodbury, N.Y. : 1994) · 2022Article
- In Vitro Flow Chamber Design for the Study of Endothelial Cell (Patho)Physiology.Journal of biomechanical engineering · 2022Review
- The Rheology of the Carotid Sinus: A Path Toward Bioinspired Intervention.Frontiers in bioengineering and biotechnology · 2021Review
- A 4D flow MRI evaluation of the impact of shear-dependent fluid viscosity on in vitro Fontan circulation flow.American journal of physiology. Heart and circulatory physiology · 2019Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
The Fontan procedure for univentricular heart defects creates a unique circulation where all pulmonary blood flow is passively supplied directly from systemic veins. Computational simulations, aimed at optimizing the surgery, have assumed blood to be a Newtonian fluid without evaluating the potential error introduced by this assumption. We compared flow behavior between a non-Newtonian blood analog (0.04% xanthan gum) and a control Newtonian fluid (45% glycerol) in a simplified model of the Fontan circulation. Particle image velocimetry was used to examine flow behavior at two different cardiac outputs and two caval blood flow distributions. Pressure and flow rates were measured at each inlet and outlet. Velocity, shear strain, and shear stress maps were derived from velocity data. Power loss was calculated from pressure, flow, and velocity data. Power loss was increased in all test conditions with xanthan gum vs. glycerol (mean 10±2.9% vs. 5.6±1.3%, p=0.032). Pulmonary blood flow distribution differed in all conditions, more so at low cardiac output. Caval blood flow mixing patterns and shear stress were also qualitatively different between the solutions in all conditions. We conclude that assuming blood to be a Newtonian fluid introduces considerable error into simulations of the Fontan circulation, where low-shear flow predominates.
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