ArticleNature microbiology2018
Human CD45 is an F-component-specific receptor for the staphylococcal toxin Panton-Valentine leukocidin.
Erratum issuedOpen access · bronzeAbstract read
In one paragraph
Article in Nature microbiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 54 papers.
0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed
7.4field-weighted citation impact, top 2% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
54 citing papers in PubMed, 86 citations in OpenAlex.
- Pre-existing antibody-mediated adverse effects prevent the clinical development of a bacterial anti-inflammatory protein.Disease models & mechanisms · 2020Trial
- Candida albicans activates Staphylococcus aureus virulence regulatory systems to drive toxin-mediated human cell death.PLoS pathogens · 2026Article
- Dissecting conserved molecular mechanisms of biological toxin activity through CRISPR screening.Biochemical Society transactions · 2026Review
- Methicillin-resistant and susceptible Staphylococcus aureus: tolerance, immune evasion and treatment.Nature reviews. Microbiology · 2026Review
- Identification of β4GALNT2 as an anti-hPIV3 factor through genome-wide CRISPR/Cas9 library screening.Emerging microbes & infections · 2025Article
- Article
- Cell targeting by the bicomponent leukocidin subunit HlgB drives Staphylococcus aureus pathophysiology.The Journal of biological chemistry · 2025Article
- Article
- Membrane protein CRISPR screen identifies RPSA as an essential host factor for porcine epidemic diarrhea virus replication.Journal of virology · 2025Article
- The Susceptibility Profiles of Human Peripheral Blood Cells toMicroorganisms · 2025Review
- Article
- A promisingClinical and experimental vaccine research · 2025Review
- ZBTB17/MIZ1 promotes peroxisome biogenesis by transcriptional regulation of PEX13.The Journal of cell biology · 2025Article
- Staphylococcal toxin PVL ruptures model membranes under acidic conditions through interactions with cardiolipin and phosphatidic acid.PLoS biology · 2025Article
- Genome-wide CRISPR/Cas9 library screen identifies C16orf62 as a host dependency factor for porcine deltacoronavirus infection.Emerging microbes & infections · 2024Article
- Exploration of compounds to inhibit the Panton-Valentine leukocidin of Staphylococcus aureus.Medical microbiology and immunology · 2024Article
- The Relative Importance of Cytotoxins Produced by Methicillin-ResistantMicroorganisms · 2024Article
- Mechanisms of host adaptation by bacterial pathogens.FEMS microbiology reviews · 2024Review
- Staphylococcus aureus Panton-Valentine Leukocidin worsens acute implant-associated osteomyelitis in humanized BRGSF mice.JBMR plus · 2024Article
- Complex Regulation of Gamma-Hemolysin Expression Impacts Staphylococcus aureus Virulence.Microbiology spectrum · 2023Article
Corrections and comments
- Commented on by
- Erratum issued
Authors and funding
21 authors at 5 institutions in 5 countries.
Angelino T Tromp *Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, The Netherlands.
Michiel Van Gent *Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, The Netherlands.ORCID http://orcid.org/0000-0003-3798-5360
Pauline AbrialCIRI, Centre International de Recherche en Infectiologie, Inserm, U1111, Université Claude Bernard Lyon 1, CNRS UMR5308, Ecole Normale Supérieure de Lyon, Université Lyon, Hospices Civils de Lyon, Lyon, France.
Amandine MartinCIRI, Centre International de Recherche en Infectiologie, Inserm, U1111, Université Claude Bernard Lyon 1, CNRS UMR5308, Ecole Normale Supérieure de Lyon, Université Lyon, Hospices Civils de Lyon, Lyon, France.
Joris P JansenDepartment of Medical Microbiology, University Medical Center Utrecht, Utrecht, The Netherlands.
Carla J C De HaasDepartment of Medical Microbiology, University Medical Center Utrecht, Utrecht, The Netherlands.
Kok P M Van KesselDepartment of Medical Microbiology, University Medical Center Utrecht, Utrecht, The Netherlands.
Bart W BardoelDepartment of Medical Microbiology, University Medical Center Utrecht, Utrecht, The Netherlands.ORCID http://orcid.org/0000-0001-6450-277X
Elisabeth KruseDepartment of Medical Microbiology, University Medical Center Utrecht, Utrecht, The Netherlands.
Emilie BourdonnayCIRI, Centre International de Recherche en Infectiologie, Inserm, U1111, Université Claude Bernard Lyon 1, CNRS UMR5308, Ecole Normale Supérieure de Lyon, Université Lyon, Hospices Civils de Lyon, Lyon, France.
Michael BoettcherDepartment of Microbiology and Immunology, UCSF Diabetes Center, Keck Center for Noncoding RNA, University of California, San Francisco, San Francisco, CA, USA.
Michael T McManusDepartment of Microbiology and Immunology, UCSF Diabetes Center, Keck Center for Noncoding RNA, University of California, San Francisco, San Francisco, CA, USA.
Christopher J DayInstitute for Glycomics, Griffith University, Gold Coast, Queensland, Australia.
Michael P JenningsInstitute for Glycomics, Griffith University, Gold Coast, Queensland, Australia.ORCID http://orcid.org/0000-0002-1027-4684
Gérard LinaCIRI, Centre International de Recherche en Infectiologie, Inserm, U1111, Université Claude Bernard Lyon 1, CNRS UMR5308, Ecole Normale Supérieure de Lyon, Université Lyon, Hospices Civils de Lyon, Lyon, France.
François VandeneschCIRI, Centre International de Recherche en Infectiologie, Inserm, U1111, Université Claude Bernard Lyon 1, CNRS UMR5308, Ecole Normale Supérieure de Lyon, Université Lyon, Hospices Civils de Lyon, Lyon, France.ORCID http://orcid.org/0000-0001-9412-7106
Jos A G Van StrijpDepartment of Medical Microbiology, University Medical Center Utrecht, Utrecht, The Netherlands.
Robert Jan LebbinkDepartment of Medical Microbiology, University Medical Center Utrecht, Utrecht, The Netherlands.
Pieter-Jan A HaasDepartment of Medical Microbiology, University Medical Center Utrecht, Utrecht, The Netherlands.
Thomas HenryCIRI, Centre International de Recherche en Infectiologie, Inserm, U1111, Université Claude Bernard Lyon 1, CNRS UMR5308, Ecole Normale Supérieure de Lyon, Université Lyon, Hospices Civils de Lyon, Lyon, France. thomas.henry@inserm.fr.ORCID http://orcid.org/0000-0002-0687-8565
András N SpaanDepartment of Medical Microbiology, University Medical Center Utrecht, Utrecht, The Netherlands. a.n.spaan@umcutrecht.nl.ORCID http://orcid.org/0000-0001-5981-7259
Heidelberg University · DEUniversité Claude Bernard Lyon 1 · FRGriffith University · AUUniversity of California, San Francisco · USUtrecht University · NL
Funding
No grant is acknowledged in the PubMed record.
Abstract
The staphylococcal bi-component leukocidins Panton-Valentine leukocidin (PVL) and γ-haemolysin CB (HlgCB) target human phagocytes. Binding of the toxins' S-components to human complement C5a receptor 1 (C5aR1) contributes to cellular tropism and human specificity of PVL and HlgCB. To investigate the role of both leukocidins during infection, we developed a human C5aR1 knock-in (hC5aR1
Indexed as
AnimalsBacterial LoadBacterial ProteinsBacterial ToxinsCell LineCRISPR-Cas SystemsDisease Models, AnimalExotoxinsHemolysin ProteinsHumansLeukocidinsLeukocyte Common AntigensMiceMice, KnockoutNeutrophilsReceptor, Anaphylatoxin C5aBacterial ProteinsBacterial ToxinsC5AR1 protein, humanExotoxinsgamma-hemolysin, Staphylococcus aureusHemolysin ProteinsLeukocidinsLeukocyte Common AntigensPanton-Valentine leukocidinPTPRC protein, humanReceptor, Anaphylatoxin C5a
Identifiers
What OpenQuestion holds
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.