ArticleNature medicine2018
Antidepressive effects of targeting ELK-1 signal transduction.
Open access · greenAbstract read
In one paragraph
Article in Nature medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 2 pooled it
2.1field-weighted citation impact, top 14% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 2 syntheses or guidelines pooled it, 43 citations in OpenAlex.
- The effectiveness of music in improving the recovery of cardiothoracic surgery: a systematic review with meta-analysis and trial sequential analysis.BMC anesthesiology · 2024Pooled it
- Transcriptomic Studies of Antidepressant Action in Rodent Models of Depression: A First Meta-Analysis.International journal of molecular sciences · 2022Pooled it
- Multi-omics characterization of chronic social defeat stress recall-activated nuclei in Arc-GFP mice.Molecular psychiatry · 2026Article
- A brain-enriched circRNA blood biomarker can predict response to SSRI antidepressants.Molecular psychiatry · 2026Article
- ELK1 promotes the progress of myeloid leukemia by hindering the differentiation of neutrophils.Experimental hematology & oncology · 2026Article
- Early-Life Adversity-Induced Epigenetic Reprogramming of Prefrontal Cortex in Rats Subjected to Maternal Separation.Biological psychiatry global open science · 2025Article
- Hippocampal Zkscan4 confers resilience to chronic stress-induced depression-like behaviors.Science advances · 2025Article
- Targeting NINJ1-Mediated Plasma Membrane Rupture in Tubular Epithelial Cell Prevents Inflammatory Response in Acute Kidney Injury.International journal of biological sciences · 2025Article
- Music prevents stress-induced depression and anxiety-like behavior in mice.Translational psychiatry · 2023Article
- The autism risk factor CHD8 is a chromatin activator in human neurons and functionally dependent on the ERK-MAPK pathway effector ELK1.Scientific reports · 2022Article
- SRF in Neurochemistry: Overview of Recent Advances in Research on the Nervous System.Neurochemical research · 2022Review
- Sortilin deletion in the prefrontal cortex and hippocampus ameliorates depressive-like behaviors in mice via regulating ASM/ceramide signaling.Acta pharmacologica Sinica · 2022Article
- Cinnamaldehyde prevents intergenerational effect of paternal depression in mice via regulating GR/miR-190b/BDNF pathway.Acta pharmacologica Sinica · 2022Article
- The Eph receptor A4 plays a role in demyelination and depression-related behavior.The Journal of clinical investigation · 2022Article
- SWI/SNF chromatin remodeler complex within the reward pathway is required for behavioral adaptations to stress.Nature communications · 2022Article
- The ERK phosphorylation levels in the amygdala predict anxiety symptoms in humans and MEK/ERK inhibition dissociates innate and learned defensive behaviors in rats.Molecular psychiatry · 2021Article
- Differential and unique patterns of synaptic miRNA expression in dorsolateral prefrontal cortex of depressed subjects.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021Article
- Chronically altered NMDAR signaling in epilepsy mediates comorbid depression.Acta neuropathologica communications · 2021Article
- Article
- c-KIT-ERK1/2 signaling activated ELK1 and upregulated carcinoembryonic antigen expression to promote colorectal cancer progression.Cancer science · 2021Article
Corrections and comments
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Authors and funding
33 authors at 4 institutions in 3 countries.
Kallia Apazoglou *Neuroscience Paris Seine-IBPS, INSERM UMRS 1130/CNRS UMR8246, Sorbonne University, Université Pierre et Marie Curie, Paris, France.
Séverine Farley *Neuroscience Paris Seine-IBPS, INSERM UMRS 1130/CNRS UMR8246, Sorbonne University, Université Pierre et Marie Curie, Paris, France.
Victor Gorgievski *Neuroscience Paris Seine-IBPS, INSERM UMRS 1130/CNRS UMR8246, Sorbonne University, Université Pierre et Marie Curie, Paris, France.
Raoul BelzeauxDepartment of Psychiatry, Douglas Mental Health University Institute, McGill University Faculty of Medicine, Montreal, Quebec, Canada.
Juan Pablo LopezDepartment of Psychiatry, Douglas Mental Health University Institute, McGill University Faculty of Medicine, Montreal, Quebec, Canada.
Julien GrenierINSERM UMR-S 1124 ERL 3649, Université Paris Descartes, Paris, France.
El Chérif IbrahimFondaMental Foundation, Créteil, France.
Marie-Anne El KhouryNeuroscience Paris Seine-IBPS, INSERM UMRS 1130/CNRS UMR8246, Sorbonne University, Université Pierre et Marie Curie, Paris, France.
Yiu C TseDepartment of Psychiatry, Douglas Mental Health University Institute, McGill University Faculty of Medicine, Montreal, Quebec, Canada.
Raphaele MongredienNeuroscience Paris Seine-IBPS, INSERM UMRS 1130/CNRS UMR8246, Sorbonne University, Université Pierre et Marie Curie, Paris, France.
Alexandre BarbéNeuroscience Paris Seine-IBPS, INSERM UMRS 1130/CNRS UMR8246, Sorbonne University, Université Pierre et Marie Curie, Paris, France.
Carlos E A de MacedoNeuroscience Paris Seine-IBPS, INSERM UMRS 1130/CNRS UMR8246, Sorbonne University, Université Pierre et Marie Curie, Paris, France.
Wojciech JaworskiNeuroscience Paris Seine-IBPS, INSERM UMRS 1130/CNRS UMR8246, Sorbonne University, Université Pierre et Marie Curie, Paris, France.
Ariane BochereauNeuroscience Paris Seine-IBPS, INSERM UMRS 1130/CNRS UMR8246, Sorbonne University, Université Pierre et Marie Curie, Paris, France.
Alejandro OrricoNeuroscience Paris Seine-IBPS, INSERM UMRS 1130/CNRS UMR8246, Sorbonne University, Université Pierre et Marie Curie, Paris, France.
Elsa IsingriniDepartment of Psychiatry, Douglas Mental Health University Institute, McGill University Faculty of Medicine, Montreal, Quebec, Canada.
Chloé GuinaudieDepartment of Psychiatry, Douglas Mental Health University Institute, McGill University Faculty of Medicine, Montreal, Quebec, Canada.
Lenka MikasovaInterdisciplinary Institute for Neuroscience, CNRS UMR 5297, Université de Bordeaux, Bordeaux, France.
Franck LouisNeuroscience Paris Seine-IBPS, INSERM UMRS 1130/CNRS UMR8246, Sorbonne University, Université Pierre et Marie Curie, Paris, France.
Sophie GautronNeuroscience Paris Seine-IBPS, INSERM UMRS 1130/CNRS UMR8246, Sorbonne University, Université Pierre et Marie Curie, Paris, France.
Laurent GrocInterdisciplinary Institute for Neuroscience, CNRS UMR 5297, Université de Bordeaux, Bordeaux, France.
Charbel MassaadINSERM UMR-S 1124 ERL 3649, Université Paris Descartes, Paris, France.
Ferah YildirimDepartment of Neuropsychiatry, Department of Psychiatry and Psychotherapy and NeuroCure Cluster of Excellence, Charité-Universitätsmedizin Berlin, Berlin, Germany.
Vincent VialouNeuroscience Paris Seine-IBPS, INSERM UMRS 1130/CNRS UMR8246, Sorbonne University, Université Pierre et Marie Curie, Paris, France.
Sylvie DumasOramacell, Paris, France.
Fabio MartiNeuroscience Paris Seine-IBPS, INSERM UMRS 1130/CNRS UMR8246, Sorbonne University, Université Pierre et Marie Curie, Paris, France.ORCID http://orcid.org/0000-0002-3604-457X
Naguib MechawarDepartment of Psychiatry, Douglas Mental Health University Institute, McGill University Faculty of Medicine, Montreal, Quebec, Canada.
Elise MoriceNeuroscience Paris Seine-IBPS, INSERM UMRS 1130/CNRS UMR8246, Sorbonne University, Université Pierre et Marie Curie, Paris, France.
Tak P WongDepartment of Psychiatry, Douglas Mental Health University Institute, McGill University Faculty of Medicine, Montreal, Quebec, Canada.ORCID http://orcid.org/0000-0001-8611-4911
Jocelyne CabocheNeuroscience Paris Seine-IBPS, INSERM UMRS 1130/CNRS UMR8246, Sorbonne University, Université Pierre et Marie Curie, Paris, France.
Gustavo TureckiDepartment of Psychiatry, Douglas Mental Health University Institute, McGill University Faculty of Medicine, Montreal, Quebec, Canada.
Bruno GirosNeuroscience Paris Seine-IBPS, INSERM UMRS 1130/CNRS UMR8246, Sorbonne University, Université Pierre et Marie Curie, Paris, France. bruno.giros@mcgill.ca.ORCID http://orcid.org/0000-0001-5876-9822
Eleni T TzavaraNeuroscience Paris Seine-IBPS, INSERM UMRS 1130/CNRS UMR8246, Sorbonne University, Université Pierre et Marie Curie, Paris, France. eleni.tzavara@inserm.fr.
Centre National de la Recherche Scientifique · FRDouglas Mental Health University Institute · CADélégation Paris 5 · FRCharité - Universitätsmedizin Berlin · DE
Funding
No grant is acknowledged in the PubMed record.
Abstract
Depression, a devastating psychiatric disorder, is a leading cause of disability worldwide. Current antidepressants address specific symptoms of the disease, but there is vast room for improvement
Indexed as
AdultAnimalsAntidepressive AgentsBehavior, AnimalDepressionets-Domain Protein Elk-1FemaleHippocampusHumansMaleMiceMiddle AgedNeuronal PlasticityRNA, MessengerSignal TransductionStress, PsychologicalAntidepressive Agentsets-Domain Protein Elk-1RNA, Messenger
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.