SynthesisBritish journal of cancer2018
Addition of ultrasound to mammography in the case of dense breast tissue: systematic review and meta-analysis.
Synthesis in British journal of cancer, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
64 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Supplemental Screening as an Adjunct to Mammography for Breast Cancer Screening in People With Dense Breasts: A Health Technology Assessment.Ontario health technology assessment series · 2023Pooled it
- Supplemental breast cancer-screening ultrasonography in women with dense breasts: a systematic review and meta-analysis.British journal of cancer · 2020Pooled it
- Ultrasound for Breast Cancer Detection Globally: A Systematic Review and Meta-Analysis.Journal of global oncology · 2019Pooled it
- Personalized breast cancer screening strategies: A systematic review and quality assessment.PloS one · 2019Pooled it
- Supplemental Breast Ultrasound in Mammography Screening for Women with Critically Dense Breasts.Cancers · 2026Article
- Convolutional-transformer fusion of ultrasound and diffuse optical tomography for breast lesion classification.Computerized medical imaging and graphics : the official journal of the Computerized Medical Imaging Society · 2026Article
- AI-Driven Breast Cancer Nuclei Segmentation, Classification, and Scoring in PR-IHC Images.Diagnostics (Basel, Switzerland) · 2026Article
- Review
- Prospective Multicenter Study Comparing Magnetic Resonance Imaging and Ultrasonography for Second Breast Cancer Surveillance in Women With Prior Breast Cancer and Dense Breasts: KBCSG-27 Trial.Journal of breast cancer · 2025Article
- Article
- Breast density in MRI: an AI-based quantification and relationship to assessment in mammography.NPJ breast cancer · 2025Article
- Using a Large Language Model for Breast Imaging Reporting and Data System Classification and Malignancy Prediction to Enhance Breast Ultrasound Diagnosis: Retrospective Study.JMIR medical informatics · 2025Article
- Variational mode directed deep learning framework for breast lesion classification using ultrasound imaging.Scientific reports · 2025Article
- Ultrasound-based deep learning radiomics for multi-stage assisted diagnosis in reducing unnecessary biopsies of BI-RADS 4A lesions.Quantitative imaging in medicine and surgery · 2025Article
- New progress in imaging diagnosis and immunotherapy of breast cancer.Frontiers in immunology · 2025Review
- Downgrading Breast Imaging Reporting and Data System categories in ultrasound using strain elastography and computer-aided diagnosis system: a multicenter, prospective study.The British journal of radiology · 2024Article
- Deep learning of mammogram images to reduce unnecessary breast biopsies: a preliminary study.Breast cancer research : BCR · 2024Article
- A bimodal nomogram as an adjunct tool to reduce unnecessary breast biopsy following discordant ultrasonic and mammographic BI-RADS assessment.European radiology · 2024Article
- A bimodal nomogram: a non-invasive tool to assist breast radiologists in decision-making.European radiology · 2024Article
- Evaluating the Role of Breast Ultrasound in Early Detection of Breast Cancer in Low- and Middle-Income Countries: A Comprehensive Narrative Review.Bioengineering (Basel, Switzerland) · 2024Review
4 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
backgroundMammography is less effective in detecting cancer in dense than in fatty breasts.
methodsWe undertook a systematic search in PubMed to identify studies on women with dense breasts who underwent screening with mammography supplemented with ultrasound. A meta-analysis was undertaken on the proportion of cancers detected only by ultrasound, out of all screen-detected cancers, and the proportion of women with negative mammography who were referred for assessment following ultrasound screening.
resultsTwenty-nine studies satisfied our inclusion criteria. The proportion of total cancers detected only by ultrasound was 0.29 (95% CI: 0.27-0.31), consistent with an approximately 40% increase in the detection of cancers compared to mammography. In the studied populations, this translated into an additional 3.8 (95% CI: 3.4-4.2) screen-detected cases per 1000 mammography-negative women. About 13% (32/248) of cancers were in situ from 17 studies with information on this subgroup. Ultrasound approximately doubled the referral for assessment in three studies with these data.
conclusionsStudies have consistently shown an increased detection of breast cancer by supplementary ultrasound screening. An inclusion of supplementary ultrasound into routine screening will need to consider the availability of ultrasound and diagnostic assessment capacities.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.