Evidence map›Paper›PMID 29736007›Full record

Trial reportBritish journal of cancer2018

Effects of high-intensity interval training on fatigue and quality of life in testicular cancer survivors.

Scott C Adams, Darren S DeLorey, Margie H Davenport, Adrian S Fairey, Scott North, Kerry S Courneya

Registry-linked trialOpen access · hybridAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in British journal of cancer, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04679233 (Feasibility and Preliminary Efficacy of Aerobic Exercise in Head and Neck Cancer Patients Undergoing Radiation Therapy), which is not on this map. Cited by 55 papers, 19 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
55citing papers in PubMed, 19 pooled it
3.7field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04679233 nawithdrawnnot on this mapstarted 2021, after this paper: background citation

Feasibility and Preliminary Efficacy of Aerobic Exercise in Head and Neck Cancer Patients Undergoing Radiation Therapy

TypeinterventionalSponsorVanderbilt UniversityRan2021 to 2021Enrolled0ConditionsHead and Neck Neoplasm, RadiotherapyArmsPrescription aerobic exercise
3 · Its place in the literature

Who cites it

55 citing papers in PubMed, 19 syntheses or guidelines pooled it, 117 citations in OpenAlex.

  1. Pooled it
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  4. Cardiovascular training for fatigue in people with cancer.The Cochrane database of systematic reviews · 2025
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  8. Physical activity and pain in people with cancer: a systematic review and meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024
    Pooled it
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  10. Rates of compliance and adherence to high-intensity interval training: a systematic review and Meta-analyses.The international journal of behavioral nutrition and physical activity · 2023
    Pooled it
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  14. The role of exercise for pain management in adults living with and beyond cancer: a systematic review and meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2023
    Pooled it
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  16. Guideline
  17. Systematic review and meta-analysis of maintenance of physical activity behaviour change in cancer survivors.The international journal of behavioral nutrition and physical activity · 2019
    Pooled it
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  20. Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Scott C AdamsFaculty of Kinesiology, Sport, and Recreation, University of Alberta, Edmonton, AB, T6G 2H9, Canada.
Darren S DeLoreyFaculty of Kinesiology, Sport, and Recreation, University of Alberta, Edmonton, AB, T6G 2H9, Canada.
Margie H DavenportFaculty of Kinesiology, Sport, and Recreation, University of Alberta, Edmonton, AB, T6G 2H9, Canada.
Adrian S FaireyDepartment of Surgery, University of Alberta, Edmonton, AB, T6G 2B7, Canada.
Scott NorthDepartment of Oncology, University of Alberta, Edmonton, AB, T6G 2R7, Canada.
Kerry S CourneyaFaculty of Kinesiology, Sport, and Recreation, University of Alberta, Edmonton, AB, T6G 2H9, Canada. kerry.courneya@ualberta.ca.
University of Alberta · CAMemorial Sloan Kettering Cancer Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTesticular cancer survivors (TCS) are at increased risk of cancer-related fatigue (CRF), psychosocial impairment, and poor mental health-related quality of life (HRQoL). Here, we examine the effects of high-intensity interval training (HIIT) on patient-reported outcomes (PROs) in TCS. Secondarily, we explore cardiorespiratory fitness as a mediator of intervention effects and select baseline characteristics as moderators of intervention effects.

methodsTCS (n = 63) were randomly assigned to 12 weeks of supervised HIIT or usual care (UC). PROs included CRF, depression, anxiety, stress, self-esteem, sleep quality, and HRQoL assessed at baseline, post-intervention, and 3-month follow-up.

resultsTCS (median 7 years postdiagnosis) completed 99% of training sessions and achieved 98% of target training intensity. ANCOVA revealed that, compared to UC, HIIT significantly improved post-intervention CRF (p = 0.003), self-esteem (p = 0.029), and multiple HRQoL domains (ps ≤ 0.05). Effects on CRF (p = 0.031) and vitality (p = 0.015) persisted at 3-month follow-up. Cardiorespiratory fitness changes mediated CRF and HRQoL improvements. CRF effects were larger for TCS with an inactive lifestyle, lower fitness, higher testosterone, and clinical fatigue at baseline.

conclusionsHIIT significantly improves CRF and HRQoL in TCS. Mediation by cardiorespiratory fitness and moderation by clinical characteristics suggests opportunities for targeted exercise interventions to optimise PROs in TCS.

Indexed as

AdultAnxietyCancer SurvivorsCardiorespiratory FitnessDepressionExercise TherapyFatigueHigh-Intensity Interval TrainingHumansMaleMiddle AgedQuality of LifeTesticular Neoplasms

Identifiers

PMID29736007
PMCPMC5959855
OpenAlexW2800495434

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.