Evidence map›Paper›PMID 29735975›Full record

Trial reportMedical science monitor : international medical journal of experimental and clinical research2018

Efficacy of Acupuncture Therapy for Chemotherapy-Related Cognitive Impairment in Breast Cancer Patients.

Taishan Tong, Chunqin Pei, Jun Chen, Qing Lv, Fuquan Zhang, Zaohuo Cheng

2 registry-linked trialsOpen access · hybridAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Medical science monitor : international medical journal of experimental and clinical research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 37 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed, 9 pooled it
4.0field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04092647 phase2unknown statusnot on this mapstarted 2023, after this paper: background citation

A Randomized Placebo-controlled Trial of Ashwagandha (Withania Somnifera) for Cognitive Dysfunction Associated With Cancer Chemotherapy.

TypeinterventionalSponsorSutter HealthRan2023 to 2025Enrolled80ConditionsChemo FogArmsAshwagandha, Placebo
NCT05283577 naactive not recruitingnot on this mapstarted 2022, after this paper: background citation

Electroacupuncture for the Management of Symptom Clusters in Cancer Patients and Survivors (EAST): A Feasibility Study

TypeinterventionalSponsorUniversity of California, IrvineRan2022 to 2026Enrolled70ConditionsCancerArmsElectroacupuncture, Sham-Electroacupuncture
3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 9 syntheses or guidelines pooled it, 64 citations in OpenAlex.

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  11. Acupuncture for chemotherapy-induced dysgeusia (AcuDysg): a randomized controlled trial.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
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  16. Methodology of analysis of cognitive impairment in longitudinal randomized clinical trials in oncology: a scoping review.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Taishan TongDepartment of Psychology and Psychiatry, The Affiliated Wuxi Mental Health Center of Nanjing Medical University, Wuxi, Jiangsu, China (mainland).
Chunqin PeiDepartment of Acupuncture and Moxibustion, The Affiliated Hospital of Jiangnan University, Wuxi, Jiangsu, China (mainland).
Jun ChenDepartment of Acupuncture and Moxibustion, The Affiliated Hospital of Jiangnan University, Wuxi, Jiangsu, China (mainland).
Qing LvDepartment of Breast Surgery, The Affiliated Hospital of Jiangnan University, Wuxi, Jiangsu, China (mainland).
Fuquan ZhangDepartment of Psychology and Psychiatry, The Affiliated Wuxi Mental Health Center of Nanjing Medical University, Wuxi, Jiangsu, China (mainland).
Zaohuo ChengDepartment of Psychology and Psychiatry, The Affiliated Wuxi Mental Health Center of Nanjing Medical University, Wuxi, Jiangsu, China (mainland).
Wuxi Fourth People's Hospital · CNWuxi People's Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND Chemotherapy can cause adverse effects such as chemotherapy-related cognitive impairment (CRCI). In this prospective study, the efficacy of traditional Chinese medicine acupuncture therapy in relieving CRCI and its impact on serum brain-derived neurotrophic factor (BDNF) are evaluated. MATERIAL AND METHODS Eighty patients were randomly divided into a treatment group and a control group with 40 patients in each group. The treatment group was treated at the following acupuncture points: Baihui (DU20), Sishencong (EX-HN1), Shenting (DU24), Zusanli (ST36), Taixi (K13), Dazhong (K14), and Juegu (GB39). Cognitive function was assessed using the functional assessment of cancer treatment cognition test (FACT-COG, version 3), the auditory-verbal learning test (AVLT), the verbal fluency test (VFT), the symbol digit modality test (SDMT), the clock-drawing test (CDT), and the trail-making test part B (TMT-B). In addition, blood serum levels of BDNF were measured before and after treatment. Correlations between change in BDNF levels and cognitive function were also analyzed. RESULTS CRCI was ameliorated in the acupuncture treatment group, with scores on FACT-COG, AVLT-recognition and CDT assessments all significantly increased (P<0.05 in all cases). In addition, serum BDNF levels after acupuncture treatment were significantly higher than before treatment ([i]t[/i]=3.242, [i]P[/i]<0.01). Moreover, the level of BDNF was positively correlated with the total score of FACT-COG, AVLT-recognition, and CDT ([i]r[/i]=0.694, 0.628, and 0.532, respectively; all P<0.05). The control group showed no statistically significant difference in any measures over the same period. CONCLUSIONS Acupuncture therapy is effective in the treatment of CRCI in breast cancer patients through a mechanism that may be related to an increase of BDNF.

Indexed as

Acupuncture TherapyAntineoplastic AgentsBrain-Derived Neurotrophic FactorBreast NeoplasmsCognitive DysfunctionDemographyFemaleHumansMiddle AgedNeuropsychological TestsTreatment OutcomeAntineoplastic AgentsBDNF protein, humanBrain-Derived Neurotrophic FactorAcupuncture - methodsBrain-Derived Neurotrophic Factor - chemical synthesisBreastmild cognitive impairment

Identifiers

PMID29735975
PMCPMC5963738
OpenAlexW2800886915

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.