Evidence map›Paper›PMID 29735719›Full record

ArticleMolecular and cellular biology2018

Reduction of Cellular Nucleic Acid Binding Protein Encoded by a Myotonic Dystrophy Type 2 Gene Causes Muscle Atrophy.

Christina Wei, Lauren Stock, Christiane Schneider-Gold, Claudia Sommer, Nikolai A Timchenko, Lubov Timchenko

Open access · bronzeAbstract read
In one paragraph

Article in Molecular and cellular biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.4field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 25 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Modeling Myotonic Dystrophy Type 2 UsingInternational journal of molecular sciences · 2023
    Review
  7. Article
  8. Review
  9. Review
  10. Article
  11. Review
  12. Myotonic dystrophy type 2: the 2020 update.Acta myologica : myopathies and cardiomyopathies : official journal of the Mediterranean Society of Myology · 2020
    Review
  13. Review
  14. Article
  15. Review
  16. Article
  17. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Christina WeiDivision of Neurology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.
Lauren StockDivision of Neurology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.
Christiane Schneider-GoldDepartment of Neurology, St. Josef Hospital, Ruhr University Bochum, Bochum, Germany.
Claudia SommerDepartment of Neurology, University of Würzburg, Würzburg, Germany.
Nikolai A TimchenkoDivision of Surgery, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.
Lubov TimchenkoDivision of Neurology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA Lubov.Timchenko@cchmc.org.
Cincinnati Children's Hospital Medical Center · USRuhr University Bochum · DEUniversity of Würzburg · DE

Funding

Myotonic Dystrophy Type 2R01AR052791 · NIAMS · CINCINNATI CHILDRENS HOSP MED CTR · PI TIMCHENKO, LUBOV T · 2005 to 2015
$3.1M
Role of Age in Liver CancerR01CA159942 · NCI · CINCINNATI CHILDRENS HOSP MED CTR · PI TIMCHENKO, NIKOLAI A. · 2011 to 2015
$1.6M
NAFLD: Mechanisms and TreatmentsR01DK102597 · NIDDK · CINCINNATI CHILDRENS HOSP MED CTR · PI TIMCHENKO, NIKOLAI A. · 2015 to 2018
$1.4M
Inhibition of GSK3 beta as potential therapy for DM1R21AR064488 · NIAMS · CINCINNATI CHILDRENS HOSP MED CTR · PI TIMCHENKO, LUBOV T · 2014 to 2015
$370k
NCI NIH HHS R01 CA159942NIAMS NIH HHS R01 AR052791NIAMS NIH HHS R21 AR064488NIDDK NIH HHS R01 DK102597
6 · The paper itself

Abstract

Myotonic dystrophy type 2 (DM2) is a neuromuscular disease caused by an expansion of intronic CCTG repeats in the

Indexed as

Age FactorsAnimalsDystroglycansFemaleHeterozygoteHomozygoteHumansMaleMiceMice, Inbred C57BLMice, KnockoutMuscle, SkeletalMuscular AtrophyMuscular Dystrophy, AnimalMyotonic DystrophyRNA-Binding ProteinsCNBP protein, humanCnbp protein, mouseDAG1 protein, humanDag1 protein, mouseDystroglycansRNA-Binding ProteinsCNBPmolecular pathologymuscle atrophymyotonic dystrophyunstable repeats

Identifiers

PMID29735719
PMCPMC6024164
OpenAlexW2802930064

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.