ArticleProceedings of the National Academy of Sciences of the United States of America2018
Dopamine receptors mediate strategy abandoning via modulation of a specific prelimbic cortex-nucleus accumbens pathway in mice.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 29 citations in OpenAlex.
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- Frontostriatal regulation of brain circuits contributes to flexible decision making.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025Article
- In vivo calcium extrusion from accumbal astrocytes reduces anxiety-like behaviors but increases compulsive-like responses and compulsive ethanol drinking in mice.Neuropharmacology · 2025Article
- Rasd2 regulates depression-like behaviors via DRD2 neurons in the prelimbic cortex afferent to nucleus accumbens core circuit.Molecular psychiatry · 2025Article
- Presurgical structural connectivity predicts postsurgical cognitive impairment in glioma patients.Brain communications · 2025Article
- Frontostriatal circuit dysfunction leads to cognitive inflexibility in neuroligin-3 R451C knockin mice.Molecular psychiatry · 2024Article
- Striatopallidal adenosine ANeuropharmacology · 2023Review
- Adolescent alcohol exposure reduces dopamine 1 receptor modulation of prelimbic neurons projecting to the nucleus accumbens and basolateral amygdala.Addiction neuroscience · 2022Article
- Nigrostriatal dopamine pathway regulates auditory discrimination behavior.Nature communications · 2022Article
- Adolescent social isolation induces distinct changes in the medial and lateral OFC-BLA synapse and social and emotional alterations in adult mice.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Article
- How Can Animal Models Inform the Understanding of Cognitive Inflexibility in Patients with Anorexia Nervosa?Journal of clinical medicine · 2022Review
- Nucleus Accumbens Core Dopamine D2 Receptor-Expressing Neurons Control Reversal Learning but Not Set-Shifting in Behavioral Flexibility in Male Mice.Frontiers in neuroscience · 2022Article
- Targeting presynaptic H3 heteroreceptor in nucleus accumbens to improve anxiety and obsessive-compulsive-like behaviors.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Therapeutic effects of anodal transcranial direct current stimulation in a rat model of ADHD.eLife · 2020Article
- A limbic circuitry involved in emotional stress-induced grooming.Nature communications · 2020Article
- Cortical Foxp2 Supports Behavioral Flexibility and Developmental Dopamine D1 Receptor Expression.Cerebral cortex (New York, N.Y. : 1991) · 2020Article
- A specific prelimbic-nucleus accumbens pathway controls resilience versus vulnerability to food addiction.Nature communications · 2020Article
- Striatal circuits for reward learning and decision-making.Nature reviews. Neuroscience · 2019Review
- Increased Cocaine Motivation Is Associated with Degraded Spatial and Temporal Representations in IL-NAc Neurons.Neuron · 2019Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The ability to abandon old strategies and adopt new ones is essential for survival in a constantly changing environment. While previous studies suggest the importance of the prefrontal cortex and some subcortical areas in the generation of strategy-switching flexibility, the fine neural circuitry and receptor mechanisms involved are not fully understood. In this study, we showed that optogenetic excitation and inhibition of the prelimbic cortex-nucleus accumbens (NAc) pathway in the mouse respectively enhances and suppresses strategy-switching ability in a cross-modal spatial-egocentric task. This ability is dependent on an intact dopaminergic tone in the NAc, as local dopamine denervation impaired the performance of the animal in the switching of tasks. In addition, based on a brain-slice preparation obtained from Drd2-EGFP BAC transgenic mice, we demonstrated direct innervation of D2 receptor-expressing medium spiny neurons (D2-MSNs) in the NAc by prelimbic cortical neurons, which is under the regulation by presynaptic dopamine receptors. While presynaptic D1-type receptor activation enhances the glutamatergic transmission from the prelimbic cortex to D2-MSNs, D2-type receptor activation suppresses this synaptic connection. Furthermore, manipulation of this pathway by optogenetic activation or administration of a D1-type agonist or a D2-type antagonist could restore impaired task-switching flexibility in mice with local NAc dopamine depletion; this restoration is consistent with the effects of knocking down the expression of specific dopamine receptors in the pathway. Our results point to a critical role of a specific prelimbic cortex-NAc subpathway in mediating strategy abandoning, allowing the switching from one strategy to another in problem solving.
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