Evidence map›Paper›PMID 29735674›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2018

Defective phagosome motility and degradation in cell nonautonomous RPE pathogenesis of a dominant macular degeneration.

Julian Esteve-Rudd, Roni A Hazim, Tanja Diemer, Antonio E Paniagua, Stefanie Volland, Ankita Umapathy, David S Williams

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
1.9field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 38 citations in OpenAlex.

  1. Article
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  3. Review
  4. A mutation inMolecular vision · 2026
    Article
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  6. Review
  7. Article
  8. Review
  9. Article
  10. Review
  11. Article
  12. Revisiting the Daily Timing of POS Phagocytosis.Advances in experimental medicine and biology · 2023
    Article
  13. Review
  14. Review
  15. Review
  16. Prph2 disease mutations lead to structural and functional defects in the RPE.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2022
    Article
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Julian Esteve-RuddDepartment of Ophthalmology and Stein Eye Institute, University of California, Los Angeles (UCLA), Los Angeles, CA 90095.
Roni A HazimDepartment of Ophthalmology and Stein Eye Institute, University of California, Los Angeles (UCLA), Los Angeles, CA 90095.
Tanja DiemerDepartment of Ophthalmology and Stein Eye Institute, University of California, Los Angeles (UCLA), Los Angeles, CA 90095.
Antonio E PaniaguaDepartment of Ophthalmology and Stein Eye Institute, University of California, Los Angeles (UCLA), Los Angeles, CA 90095.
Stefanie VollandDepartment of Ophthalmology and Stein Eye Institute, University of California, Los Angeles (UCLA), Los Angeles, CA 90095.
Ankita UmapathyDepartment of Ophthalmology and Stein Eye Institute, University of California, Los Angeles (UCLA), Los Angeles, CA 90095.
David S WilliamsDepartment of Ophthalmology and Stein Eye Institute, University of California, Los Angeles (UCLA), Los Angeles, CA 90095; dswilliams@ucla.edu.ORCID 0000-0002-7758-3932
University of California, Los Angeles · US

Funding

Vision Research Core at UCLAP30EY000331 · NEI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DAVID S WILLIAMS · 1985 to 2026
$16.8M
The Photoreceptor CiliumR01EY013408 · NEI · UNIVERSITY OF CALIFORNIA SAN DIEGO · PI WILLIAMS, DAVID S · 2001 to 2017
$3.8M
RPE cell biology, aging, and diseaseR01EY027442 · NEI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI WILLIAMS, DAVID S · 2017 to 2021
$2.6M
CFH in RPE cell biology and diseaseF31EY026805 · NEI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI HAZIM, RONI · 2017 to 2018
$65k
NEI NIH HHS F31 EY026805NEI NIH HHS P30 EY000331NEI NIH HHS R01 EY013408NEI NIH HHS R01 EY027442
6 · The paper itself

Abstract

Stargardt macular dystrophy 3 (STGD3) is caused by dominant mutations in the

Indexed as

Disease Models, AnimalMutationAnimalsCell MovementCells, CulturedEye ProteinsGenes, DominantHumansMacular DegenerationMembrane ProteinsMiceMice, TransgenicPhagosomesPhotoreceptor CellsRetinal Pigment EpitheliumElovl4 protein, mouseEye ProteinsMembrane ProteinsELOVL4phagocytosisphotoreceptorStargardt

Identifiers

PMID29735674
PMCPMC6003516
OpenAlexW2803510612

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.