ArticleProceedings of the National Academy of Sciences of the United States of America2018
Linked genetic variation and not genome structure causes widespread differential expression associated with chromosomal inversions.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 2 of them syntheses that pooled it.
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Who cites it
34 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- A cosmopolitan inversion facilitates seasonal adaptation in overwintering Drosophila.Genetics · 2024Pooled it
- Analysis of genetically determined gene expression suggests role of inflammatory processes in exfoliation syndrome.BMC genomics · 2023Pooled it
- Parallel clines of chromosomal inversion frequencies in seaweed flies are associated with thermal variation.Heredity · 2026Article
- The Genomic Imprint of Chromosomal Inversions and Demographic History in Island Populations of Deer Mice.Molecular biology and evolution · 2025Article
- The Evolution of Locally Adaptive Chromosome Inversions in Mimulus guttatus.Molecular ecology · 2025Article
- A Balanced Inversion Polymorphism Exhibits a Dominance Reversal at the Gene Expression Level that Depends on Developmental Context.Molecular biology and evolution · 2025Article
- The genomic imprint of chromosomal inversions and demographic history in island populations of deer mice.bioRxiv : the preprint server for biology · 2025Article
- Structural Variations Associated with Adaptation and Coat Color in Qinghai-Tibetan Plateau Cattle.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- The potential of inversions to accumulate balanced sexual antagonism is supported by simulations andeLife · 2025Article
- Inversions encounter relaxed genetic constraints and balance birth and death of TPS genes in Curcuma.Nature communications · 2024Article
- Long-Term Maintenance of Complex Chromosomal Inversion Polymorphism inEcology and evolution · 2024Article
- Pervasive tissue-, genetic background-, and allele-specific gene expression effects in Drosophila melanogaster.PLoS genetics · 2024Article
- Genomic structural variation contributes to evolved changes in gene expression in high-altitude Tibetan sheep.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- High-resolution mapping of SrTm4, a recessive resistance gene to wheat stem rust.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2023Article
- Karyotype differentiation in theComparative cytogenetics · 2023Article
- NewInternational journal of molecular sciences · 2022Article
- Distinct signals of clinal and seasonal allele frequency change at eQTLs in Drosophila melanogaster.Evolution; international journal of organic evolution · 2022Article
- Genetic architecture of repeated phenotypic divergence in Littorina saxatilis ecotype evolution.Evolution; international journal of organic evolution · 2022Article
- Supergene potential of a selfish centromere.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022Article
- The relevance of chromatin architecture to genome rearrangements inPhilosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022Article
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6 authors.
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Abstract
Chromosomal inversions are widely thought to be favored by natural selection because they suppress recombination between alleles that have higher fitness on the same genetic background or in similar environments. Nonetheless, few selected alleles have been characterized at the molecular level. Gene expression profiling provides a powerful way to identify functionally important variation associated with inversions and suggests candidate phenotypes. However, altered genome structure itself might also impact gene expression by influencing expression profiles of the genes proximal to inversion breakpoint regions or by modifying expression patterns genome-wide due to rearranging large regulatory domains. In natural inversions, genetic differentiation and genome structure are inextricably linked. Here, we characterize differential expression patterns associated with two chromosomal inversions found in natural
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