ArticleGenome research2018
The peopling of South America and the trans-Andean gene flow of the first settlers.
Article in Genome research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 58 citations in OpenAlex.
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- Vector mapping and bloodmeal metabarcoding demonstrate risk of urban Chagas disease transmission in Caracas, Venezuela.PLoS neglected tropical diseases · 2023Article
- A Timeframe for SARS-CoV-2 Genomes: A Proof of Concept for Postmortem Interval Estimations.International journal of molecular sciences · 2022Article
- Uncovering Signals of Positive Selection in Peruvian Populations from Three Ecological Regions.Molecular biology and evolution · 2022Article
- Clotting factor genes are associated with preeclampsia in high-altitude pregnant women in the Peruvian Andes.American journal of human genetics · 2022Article
- A genomic perspective on South American human history.Genetics and molecular biology · 2022Article
- History of canids in Chile and impacts on prey adaptations.Ecology and evolution · 2021Article
- Ancient mitochondrial genomes from the Argentinian Pampas inform the early peopling of the Southern Cone of South America.iScience · 2021Article
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- Generations of genomes: advances in paleogenomics technology and engagement for Indigenous people of the Americas.Current opinion in genetics & development · 2020Review
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- Exome Sequencing of Native Populations From the Amazon Reveals Patterns on the Peopling of South America.Frontiers in genetics · 2020Article
- Rapid radiation of humans in South America after the last glacial maximum: A radiocarbon-based study.PloS one · 2020Article
- Fine-scale genomic analyses of admixed individuals reveal unrecognized genetic ancestry components in Argentina.PloS one · 2020Article
- Dissecting the Pre-Columbian Genomic Ancestry of Native Americans along the Andes-Amazonia Divide.Molecular biology and evolution · 2019Article
- Biogeographical origin and timing of the founder ichthyosis TGM1 c.1187G > A mutation in an isolated Ecuadorian population.Scientific reports · 2019Article
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Authors and funding
12 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Genetic and archaeological data indicate that the initial Paleoindian settlers of South America followed two entry routes separated by the Andes and the Amazon rainforest. The interactions between these paths and their impact on the peopling of South America remain unclear. Analysis of genetic variation in the Peruvian Andes and regions located south of the Amazon River might provide clues on this issue. We analyzed mitochondrial DNA variation at different Andean locations and >360,000 autosomal SNPs from 28 Native American ethnic groups to evaluate different trans-Andean demographic scenarios. Our data reveal that the Peruvian Altiplano was an important enclave for early Paleoindian expansions and point to a genetic continuity in the Andes until recent times, which was only marginally affected by gene flow from the Amazonian lowlands. Genomic variation shows a good fit with the archaeological evidence, indicating that the genetic interactions between the descendants of the settlers that followed the Pacific and Atlantic routes were extremely limited.
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