Evidence map›Paper›PMID 29735574›Full record

ArticlePediatrics2018

Management of Type 1 Diabetes With a Very Low-Carbohydrate Diet.

Belinda S Lennerz, Anna Barton, Richard K Bernstein, R David Dikeman, Carrie Diulus, Sarah Hallberg, Erinn T Rhodes, Cara B Ebbeling, Eric C Westman, William S Yancy and 1 more

5 registry-linked trialsOpen access · greenAbstract read
In one paragraph

Article in Pediatrics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 5 registered trials, which are not on this map. Cited by 76 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
76citing papers in PubMed, 1 pooled it
10.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03710928 narecruitingnot on this mapstarted 2020, after this paper: background citation

Type 1 Diabetes Management Using a Very Low Carbohydrate Versus Standard Diet

TypeinterventionalSponsorBoston Children's HospitalRan2020 to 2026Enrolled32ConditionsType1diabetesArmsvery low carbohydrate diet, standard carbohydrate diet
NCT05031429 nacompletednot on this mapstarted 2022, after this paper: background citation

Time Limited Eating in New-Onset Type 1 Diabetes: Feasibility, Acceptability, and Effect on β-cell Function

TypeinterventionalSponsorChildren's Hospital Los AngelesRan2022 to 2023Enrolled12ConditionsType 1 DiabetesArmsTime Limited Eating
NCT05723445 narecruitingnot on this mapstarted 2023, after this paper: background citation

The Effects of a Low Glycemic Load Diet on Dysglycemia and Body Composition in Adults With Cystic Fibrosis-Related Diabetes

TypeinterventionalSponsorRhode Island HospitalRan2023 to 2026Enrolled15ConditionsCystic Fibrosis, Cystic Fibrosis-related Diabetes, Cystic Fibrosis With Intestinal ManifestationsArmsLow Glycemic Load Diet
NCT05872711 naunknown statusnot on this mapstarted 2023, after this paper: background citation

Low Carbohydrate Versus Mediterranean Diet in Adolescents With Type 1 Diabetes: A Randomized Control Trial

TypeinterventionalSponsorSheba Medical CenterRan2023 to 2025Enrolled40ConditionsType 1 DiabetesArmsLow carbohydrate diet
NCT05899166 narecruitingnot on this mapstarted 2024, after this paper: background citation

Effect of Dietary Carbohydrate on Diabetes Control and Beta Cell Function in Children With Newly Diagnosed Diabetes

TypeinterventionalSponsorBoston Children's HospitalRan2024 to 2029Enrolled52ConditionsDiabetes Mellitus, Type 1ArmsKetogenic diet, food delivery and education, Standard diet, food delivery and education
3 · Its place in the literature

Who cites it

76 citing papers in PubMed, 1 synthesis or guideline pooled it, 138 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Trial
  4. Trial
  5. Trial
  6. Trial
  7. Trial
  8. Review
  9. Article
  10. Article
  11. Review
  12. Review
  13. Article
  14. Article
  15. Prolonging Partial Remission in Type 1 Diabetes: The Role of Low-Carbohydrate Diet: A Literature Review.Diabetes, metabolic syndrome and obesity : targets and therapy · 2026
    Review
  16. Review
  17. Review
  18. Review
  19. Article
  20. Review

16 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 7 institutions in 1 country.

Belinda S LennerzDivision of Endocrinology, and.
Anna BartonRichmond Diabetes and Endocrinology, Bon Secours Medical Group, Richmond, Virginia.
Richard K BernsteinNew York Diabetes Center, Mamaroneck, New York.
R David DikemanLockheed Martin, Honolulu, Hawaii.
Carrie DiulusCrystal Clinic Orthopaedic Center, Akron, Ohio.
Sarah HallbergVirta Health and Indiana University Health, School of Medicine, Indiana University, Indianapolis, Indiana; and.
Erinn T RhodesDivision of Endocrinology, and.
Cara B EbbelingDivision of Endocrinology, and.
Eric C WestmanDuke University Medical Center, Durham, North Carolina.
William S YancyDuke University Medical Center, Durham, North Carolina.
David S LudwigDivision of Endocrinology, and david.ludwig@childrens.harvard.edu.
Boston Children's Hospital · USDuke Medical Center · USBon Secours Health System · USHarvard University · USIndiana University Health · USLockheed Martin (United States) · USOrthopaedic Center · US

Funding

Harvard Clinical and Translational Science Center (UL1)UL1TR000170 · NCATS · HARVARD MEDICAL SCHOOL · PI NADLER, LEE MARSHALL · 2012 to 2013
$31.4M
CAREER DEVELOPMENT IN DIABETES RESEARCH FOR PEDIATRIC ENDOCRINOLOGISTSK12DK094721 · NIDDK · BOSTON CHILDREN'S HOSPITAL · PI LAFFEL, LORI M, WHITE, MORRIS F. · 2011 to 2021
$6.3M
Effects of Diet on Hormones, Metabolism and Body WeightK24DK082730 · NIDDK · BOSTON CHILDREN'S HOSPITAL · PI LUDWIG, DAVID S · 2009 to 2018
$1.6M
NCATS NIH HHS UL1 TR000170NIDDK NIH HHS K12 DK094721NIDDK NIH HHS K24 DK082730
6 · The paper itself

Abstract

objectivesTo evaluate glycemic control among children and adults with type 1 diabetes mellitus (T1DM) who consume a very low-carbohydrate diet (VLCD).

methodsWe conducted an online survey of an international social media group for people with T1DM who follow a VLCD. Respondents included adults and parents of children with T1DM. We assessed current hemoglobin A1c (HbA1c) (primary measure), change in HbA1c after the self-reported beginning of the VLCD, total daily insulin dose, and adverse events. We obtained confirmatory data from diabetes care providers and medical records.

resultsOf 316 respondents, 131 (42%) were parents of children with T1DM, and 57% were of female sex. Suggestive evidence of T1DM (based on a 3-tier scoring system in which researchers took into consideration age and weight at diagnosis, pancreatic autoimmunity, insulin requirement, and clinical presentation) was obtained for 273 (86%) respondents. The mean age at diagnosis was 16 ± 14 years, the duration of diabetes was 11 ± 13 years, and the time following a VLCD was 2.2 ± 3.9 years. Participants had a mean daily carbohydrate intake of 36 ± 15 g. Reported mean HbA1c was 5.67% ± 0.66%. Only 7 (2%) respondents reported diabetes-related hospitalizations in the past year, including 4 (1%) for ketoacidosis and 2 (1%) for hypoglycemia.

conclusionsExceptional glycemic control of T1DM with low rates of adverse events was reported by a community of children and adults who consume a VLCD. The generalizability of these findings requires further studies, including high-quality randomized controlled trials.

Indexed as

Diet, Carbohydrate-RestrictedAdultBlood GlucoseChildDiabetes Mellitus, Type 1FemaleGlycated HemoglobinHospitalizationHumansHypoglycemic AgentsInsulinMalePersonal SatisfactionPhysician-Patient RelationsSurveys and QuestionnairesBlood GlucoseGlycated HemoglobinHypoglycemic AgentsInsulin

Identifiers

PMID29735574
PMCPMC6034614
OpenAlexW2802537028

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.