Evidence map›Paper›PMID 29735567›Full record

SynthesisAntimicrobial agents and chemotherapy2018

Population Pharmacokinetic Model and Meta-analysis of Outcomes of Amphotericin B Deoxycholate Use in Adults with Cryptococcal Meningitis.

Katharine E Stott, Justin Beardsley, Sarah Whalley, Freddie Mukasa Kibengo, Nguyen Thi Hoang Mai, Nguyễn Lê Nhu' Tùng, Ngo Thi Kim Cuc, Ruwanthi Kolamunnage-Dona, William Hope, Jeremy Day

Erratum issuedAbstract readMeta-Analysis
In one paragraph

Synthesis in Antimicrobial agents and chemotherapy, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Observational
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Katharine E StottAntimicrobial Pharmacodynamics and Therapeutics Laboratory, Department of Molecular and Clinical Pharmacology, Institute of Translational Medicine, University of Liverpool, Liverpool, United Kingdom.ORCID 0000-0001-7079-7957
Justin BeardsleyOxford University Clinical Research Unit, Ho Chi Minh City, Vietnam.
Sarah WhalleyAntimicrobial Pharmacodynamics and Therapeutics Laboratory, Department of Molecular and Clinical Pharmacology, Institute of Translational Medicine, University of Liverpool, Liverpool, United Kingdom.
Freddie Mukasa KibengoMRC/UVRI Uganda Research Unit on AIDS, Entebbe, Uganda.
Nguyen Thi Hoang MaiHospital for Tropical Diseases, Ho Chi Minh City, Vietnam.
Nguyễn Lê Nhu' TùngHospital for Tropical Diseases, Ho Chi Minh City, Vietnam.
Ngo Thi Kim CucHospital for Tropical Diseases, Ho Chi Minh City, Vietnam.
Ruwanthi Kolamunnage-DonaDepartment of Biostatistics, Institute of Translational Medicine, University of Liverpool, Liverpool, United Kingdom.
William HopeAntimicrobial Pharmacodynamics and Therapeutics Laboratory, Department of Molecular and Clinical Pharmacology, Institute of Translational Medicine, University of Liverpool, Liverpool, United Kingdom hopew@liverpool.ac.uk.
Jeremy DayOxford University Clinical Research Unit, Ho Chi Minh City, Vietnam.

Funding

Medical Research Council G1100684Wellcome TrustWellcome Trust 203919/Z/16/ZWellcome Trust WT097147MA
6 · The paper itself

Abstract

There is a limited understanding of the population pharmacokinetics (PK) and pharmacodynamics (PD) of amphotericin B deoxycholate (DAmB) for cryptococcal meningitis. A PK study was conducted in

Indexed as

AdultAgedAmphotericin BAntifungal AgentsDeoxycholic AcidDrug CombinationsFemaleHumansMaleMeningitis, CryptococcalMiddle AgedMonte Carlo MethodProspective StudiesYoung AdultAmphotericin Bamphotericin B, deoxycholate drug combinationAntifungal AgentsDeoxycholic AcidDrug Combinationsamphotericin B deoxycholatecryptococcal meningitismeta-analysispharmacodynamicspharmacokineticspopulation pharmacokinetics

Identifiers

PMID29735567
PMCPMC6021666

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.