ArticleThe Journal of biological chemistry2018
Smad4 deficiency impairs chondrocyte hypertrophy via the Runx2 transcription factor in mouse skeletal development.
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Article in The Journal of biological chemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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27citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
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Who cites it
27 citing papers in PubMed, 40 citations in OpenAlex.
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- Adipose tissue-derived extracellular vesicles aggravate temporomandibular joint osteoarthritis associated with obesity.Clinical and translational medicine · 2024Article
- Cellular and Molecular Mechanisms of Heterotopic Ossification in Fibrodysplasia Ossificans Progressiva.Biomedicines · 2024Review
- The roles and regulatory mechanisms of TGF-β and BMP signaling in bone and cartilage development, homeostasis and disease.Cell research · 2024Review
- DLX5 promotesGenes & diseases · 2023Article
- Methylphenidate Promotes Premature Growth Plate Closure: In Vitro Evidence.International journal of molecular sciences · 2023Article
- Protein phosphatase PPM1A inhibition attenuates osteoarthritis via regulating TGF-β/Smad2 signaling in chondrocytes.JCI insight · 2023Article
- Pulsed Electromagnetic Field Promotes Bone Anabolism in Postmenopausal Osteoporosis through the miR-6976/BMP/Smad4 Axis.Journal of tissue engineering and regenerative medicine · 2023Article
- SMAD4 contributes to chondrocyte and osteocyte development.Journal of cellular and molecular medicine · 2022Review
- Transcriptional networks controlling stromal cell differentiation.Nature reviews. Molecular cell biology · 2021Review
- Acromelic dysplasias: how rare musculoskeletal disorders reveal biological functions of extracellular matrix proteins.Annals of the New York Academy of Sciences · 2021Article
- Comparison of the Microsatellite Distribution Patterns in the Genomes of Euarchontoglires at the Taxonomic Level.Frontiers in genetics · 2021Article
- Article
- Mesenchymal stem cell-derived exosomal microRNA-136-5p inhibits chondrocyte degeneration in traumatic osteoarthritis by targeting ELF3.Arthritis research & therapy · 2020Article
- MicroRNA-27b targets CBFB to inhibit differentiation of human bone marrow mesenchymal stem cells into hypertrophic chondrocytes.Stem cell research & therapy · 2020Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 2 countries.
Jianyun YanFrom the Department of Developmental and Regenerative Biology, The Mindich Child Health and Development Institute, and The Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, New York, New York 10029.
Jun LiFrom the Department of Developmental and Regenerative Biology, The Mindich Child Health and Development Institute, and The Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, New York, New York 10029.
Jun HuFrom the Department of Developmental and Regenerative Biology, The Mindich Child Health and Development Institute, and The Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, New York, New York 10029.
Lu ZhangFrom the Department of Developmental and Regenerative Biology, The Mindich Child Health and Development Institute, and The Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, New York, New York 10029.
Chengguo Weithe Renal Division of the Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York 10029.
Nishat SultanaFrom the Department of Developmental and Regenerative Biology, The Mindich Child Health and Development Institute, and The Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, New York, New York 10029.
Xiaoqiang CaiFrom the Department of Developmental and Regenerative Biology, The Mindich Child Health and Development Institute, and The Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, New York, New York 10029.
Weijia Zhangthe Renal Division of the Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York 10029.
Chen-Leng CaiFrom the Department of Developmental and Regenerative Biology, The Mindich Child Health and Development Institute, and The Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, New York, New York 10029, chenleng.cai@mssm.edu.
Icahn School of Medicine at Mount Sinai · USChild Health and Development Institute · US
Funding
TRAINING PROGRAM IN MOLECULAR AND CELLULAR CARDIOLOGYT32HL007824 · NHLBI · MOUNT SINAI SCHOOL OF MEDICINE OF NYU · PI GELB, BRUCE D · 1995 to 2022
$8.6MGenetic and Molecular Investigation of Tbx20 in Cardiac DevelopmentR01HL095810 · NHLBI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI CAI, CHENLENG · 2010 to 2014
$2.1MT-box transcription factor Tbx2 in coronary vascular development and diseaseR01HL131735 · NHLBI · INDIANA UNIVERSITY INDIANAPOLIS · PI CAI, CHENLENG · 2017 to 2020
$2.0MTbx1 and canonical Wnt signaling in the second heart fieldR56HL129807 · NHLBI · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI CAI, CHENLENG, MORROW, BERNICE E · 2015 to 2015
$705kT-Box Transcription Factor Tbx20 in Cardiac Development, Function and DiseaseK02HL094688 · NHLBI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI CAI, CHENLENG · 2009 to 2013
$512kNHLBI NIH HHS K02 HL094688NHLBI NIH HHS R01 HL095810NHLBI NIH HHS R01 HL131735NHLBI NIH HHS R56 HL129807NHLBI NIH HHS T32 HL007824
Abstract
Chondrocyte hypertrophy is the terminal step in chondrocyte differentiation and is crucial for endochondral bone formation. How signaling pathways regulate chondrocyte hypertrophic differentiation remains incompletely understood. In this study, using a
Indexed as
Bone DevelopmentGene DeletionGene Expression Regulation, DevelopmentalAnimalsCell DifferentiationCell ProliferationChondrocytesChondrogenesisCore Binding Factor Alpha 1 SubunitHypertrophyMiceOsteochondrodysplasiasSmad4 ProteinCore Binding Factor Alpha 1 SubunitRunx2 protein, mouseSmad4 ProteinSmad4 protein, mousebonechondrocyteChondrocyte differentiationChondrocyte hypertrophychondrogenesisdevelopmentEndochondral bone formationmouseRunx2signalingSmad4SMAD transcription factor
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.