Evidence map›Paper›PMID 29735523›Full record

ArticleInfection and immunity2018

A Capsular Polysaccharide-Specific Antibody Alters Streptococcus pneumoniae Gene Expression during Nasopharyngeal Colonization of Mice.

Christopher R Doyle, Jee-Young Moon, Johanna P Daily, Tao Wang, Liise-Anne Pirofski

Open access · bronzeAbstract read
In one paragraph

Article in Infection and immunity, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 25 citations in OpenAlex.

  1. Norepinephrine derepresses the Fur regulon ofJournal of bacteriology · 2026
    Article
  2. Phage and endolysin-based inhibition ofFrontiers in cellular and infection microbiology · 2026
    Review
  3. Article
  4. Article
  5. Effects of human immunoglobulin A onMicrobiology spectrum · 2025
    Article
  6. Article
  7. Article
  8. Alternate Antimicrobial Therapies and Their Companion Tests.Diagnostics (Basel, Switzerland) · 2023
    Review
  9. Article
  10. Review
  11. Article
  12. Diverse Mechanisms of Protective Anti-Pneumococcal Antibodies.Frontiers in cellular and infection microbiology · 2022
    Review
  13. Article
  14. The PTS Components inMicroorganisms · 2021
    Article
  15. Article
  16. Article
  17. Article
  18. Monoclonal antibody-based therapies for bacterial infections.Current opinion in infectious diseases · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Christopher R DoyleDivision of Infectious Diseases, Department of Medicine, Albert Einstein College of Medicine & Montefiore Medical Center, Bronx, New York, USA.
Jee-Young MoonDepartment of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, New York, USA.
Johanna P DailyDivision of Infectious Diseases, Department of Medicine, Albert Einstein College of Medicine & Montefiore Medical Center, Bronx, New York, USA.
Tao WangDepartment of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, New York, USA.
Liise-Anne PirofskiDivision of Infectious Diseases, Department of Medicine, Albert Einstein College of Medicine & Montefiore Medical Center, Bronx, New York, USA l.pirofski@einstein.yu.edu.
Albert Einstein College of Medicine · USMontefiore Medical Center · US

Funding

WORD PROCESSORP30CA013330 · NCI · YESHIVA UNIVERSITY · PI STEVEN C. ALMO · 1985 to 2026
$111.2M
Geographic Medicine and Emerging InfectionsT32AI070117 · NIAID · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI WEISS, LOUIS M. · 2008 to 2023
$5.1M
Effects of aging and HIV infection on the response to pneumococcal vaccineR01AG045044 · NIA · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI PIROFSKI, LIISE-ANNE · 2014 to 2018
$2.5M
Antibody therapy for pneumococcal diseaseR01AI123654 · NIAID · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI PIROFSKI, LIISE-ANNE · 2017 to 2021
$2.1M
Develop and Apply a Novel Genome-wide Mendelian Randomization Method to Examine Relationship between Obesity and Lung CancerR21CA202529 · NCI · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI HO, GLORIA YUEN FUN, WANG, TAO · 2016 to 2017
$408k
NCI NIH HHS P30 CA013330NCI NIH HHS R21 CA202529NIAID NIH HHS R01 AI123654NIAID NIH HHS T32 AI070117NIA NIH HHS R01 AG045044
6 · The paper itself

Abstract

Pneumococcal conjugate vaccines (PCV) elicit opsonophagocytic (opsonic) antibodies to pneumococcal capsular polysaccharides (PPS) and reduce nasopharyngeal (NP) colonization by vaccine-included

Indexed as

AnimalsAntibodies, BacterialAntibodies, MonoclonalBacterial CapsulesFemaleGene ExpressionMiceMice, Inbred C57BLNasopharynxOxidative StressPneumococcal VaccinesStreptococcus pneumoniaeAntibodies, BacterialAntibodies, MonoclonalPneumococcal Vaccinesantibody functioncapsuleiron acquisitionmonoclonal antibodiesnasopharyngeal colonizationpneumococcusserotype 3Streptococcus pneumoniae

Identifiers

PMID29735523
PMCPMC6013671
OpenAlexW2799909927

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.