Evidence map›Paper›PMID 29735520›Full record

ArticleInfection and immunity2018

Identification of Specific Components of the Eicosanoid Biosynthetic and Signaling Pathway Involved in Pathological Inflammation during Intra-abdominal Infection with Candida albicans and Staphylococcus aureus.

Mélanie A C Ikeh, Paul L Fidel, Mairi C Noverr

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Infection and immunity, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 12 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Microbiology (Reading, England) · 2020
    Article
  5. Esmolol inhibits inflammation and apoptosis in the intestinal tissue via the overexpression of NF-κB-p65 in the early stage sepsis rats.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2020
    Article
  6. Article
  7. Applying the Host-Microbe Damage Response Framework toJournal of fungi (Basel, Switzerland) · 2020
    Review
  8. Article
  9. Fungal-Bacterial Interactions in Health and Disease.Pathogens (Basel, Switzerland) · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Mélanie A C IkehDepartment of Oral and Craniofacial Biology, Dental School, Louisiana State University Health Sciences Center, New Orleans, Louisiana, USA.
Paul L FidelDepartment of Oral and Craniofacial Biology, Dental School, Louisiana State University Health Sciences Center, New Orleans, Louisiana, USA.
Mairi C NoverrDepartment of Oral and Craniofacial Biology, Dental School, Louisiana State University Health Sciences Center, New Orleans, Louisiana, USA mnover@lsuhsc.edu.
Louisiana State University Health Sciences Center New Orleans · US

Funding

Tracking & Evaluation CoreU54GM104940 · NIGMS · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · PI AUGUSTO C. OCHOA · 2012 to 2026
$69.1M
Host and microbial factors promoting synergistic mortality during polymicrobial intra-abdominal infections with Candida albicans and Staphylococcus aureusR01AI116025 · NIAID · TULANE UNIVERSITY OF LOUISIANA · PI NOVERR, MAIRI C · 2015 to 2019
$1.8M
NIAID NIH HHS R01 AI116025NIGMS NIH HHS U54 GM104940
6 · The paper itself

Abstract

Polymicrobial intra-abdominal infections (IAIs) are a significant cause of morbidity and mortality, particularly when fungal pathogens are involved. Our experimental murine model of IAI involving intraperitoneal inoculation of

Indexed as

AnimalsCandida albicansCandidiasisDisease Models, AnimalEicosanoidsInflammationIntraabdominal InfectionsMiceSignal TransductionStaphylococcal InfectionsStaphylococcus aureusEicosanoidsCandida albicansinflammationintra-abdominal infectionlethalityMRSApharmacological inhibitionpolymicrobial infectionprostaglandin E2signaling pathwaytherapeutic targets

Identifiers

PMID29735520
PMCPMC6013663
OpenAlexW2801391717

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.