Evidence map›Paper›PMID 29735435›Full record

ArticleNan fang yi ke da xue xue bao = Journal of Southern Medical University2018

[Tumor necrosis factor-α and transforming growth factor-β

Bo Yang, Qing Luo, Quan Kang, Jian Wang, Cheng Xiao, Zhi-Peng Li, Meng-Jia Gong, Yang Bi

Abstract read
PubMed Full text at PMC
In one paragraph

Article in Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Bo Yang1Department of Hepatology, Children's Hospital of Chongqing Medical University, Chongqing 400014, China; 2Laboratory of Stem Cell Biology and Therapy, Children's Hospital of Chongqing Medical University, Ministry of Education Key Laboratory of Child Development and Disorders, China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Chongqing Key Laboratory of Pediatrics, Chongqing 400014, China. E-mail: 527247768@qq.com.
Qing Luo
Quan Kang
Jian Wang
Cheng Xiao
Zhi-Peng Li
Meng-Jia Gong
Yang Bi
Children's Hospital of Chongqing Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo investigate the changes of tumor necrosis factor-α (TNF-α) and transforming growth factor-β

methodsBalb/c mice were subjected to bile duct ligation (BDL), and serum biochemical parameters were measured and hepatic histopathology was observed using HE staining to evaluate the modeling of cholestatic cirrhosis. Immunohistochemistry and Western blotting were used to detect the changes of TNF-α and TGF-β

resultsThe mice receiving BDL showed significantly increased blood biochemical parameters (P<0.05), and HE staining revealed obviously increased collagen fibers in the liver with significantly increased expressions of TNF-α and TGF-β

conclusionCommon bile duct ligation can induce conditions simulating cholestatic cirrhosis in mice. TNF-α and TGF-β

Indexed as

Cell DifferentiationAnimalsCell LineKeratin-18Keratin-19LigationLiverLiver CirrhosisMiceMice, Inbred BALB CStem CellsTransforming Growth Factor beta1Tumor Necrosis Factor-alphaKeratin-18Keratin-19Transforming Growth Factor beta1Tumor Necrosis Factor-alpha

Identifiers

PMID29735435
PMCPMC6765666
OpenAlexW2808500667

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.