Evidence map›Paper›PMID 29735423›Full record

ArticleInternational journal of cardiology2018

Association of positive well-being with reduced cardiac repolarization abnormalities in the First National Health and Nutrition Examination Survey.

Nino Isakadze, Elsayed Z Soliman, Viola Vaccarino, William Whang, Rachel Lampert, J Douglas Bremner, Amit J Shah

Abstract read
In one paragraph

Article in International journal of cardiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Nino IsakadzeDivision of Medicine, Emory University School of Medicine, Atlanta, GA, United States.
Elsayed Z SolimanEpidemiological Cardiology Research Center, Department of Epidemiology and Prevention, Wake Forest School of Medicine, Winston Salem, NC, United States; Section on Cardiology, Department of Internal Medicine, Wake Forest School of Medicine, Winston Salem, NC, United States.
Viola VaccarinoDepartment of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA, United States; Department of Medicine, Division of Cardiology, Emory University School of Medicine, Atlanta, GA, United States.
William WhangDivision of Cardiology, Mount Sinai Medical Center, NY, United States.
Rachel LampertDepartment of Internal Medicine, Division of Cardiovascular Medicine, Yale University School of Medicine, New Haven, CT, United States.
J Douglas BremnerDepartment of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA, United States.
Amit J ShahDepartment of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA, United States; Department of Medicine, Division of Cardiology, Emory University School of Medicine, Atlanta, GA, United States; Division of Cardiology, Department of Medicine, Atlanta Veterans Affairs Medical Center, Atlanta, GA, United States. Electronic address: ajshah3@emory.edu.

Funding

Implementing a Maternal health and PRegnancy Outcomes Vision for Everyone (IMPROVE)UL1TR002378 · NCATS · EMORY UNIVERSITY · PI Andres J Garcia, Elizabeth O. Ofili · 2017 to 2026
$92.1M
Atlanta Clinical and Translational Science Institute (ACTSI) RenewalUL1TR000454 · NCATS · EMORY UNIVERSITY · PI STEPHENS, DAVID S · 2012 to 2016
$25.8M
Neural Circuits in Women with Abuse and PTSDR01MH056120 · NIMH · YALE UNIVERSITY · PI BREMNER, JAMES DOUGLAS · 1999 to 2011
$5.0M
Atlanta Clinical and Translational Science Institute (ACTSI) RenewalKL2TR000455 · NCATS · EMORY UNIVERSITY · PI STEPHENS, DAVID S · 2012 to 2016
$2.9M
Mechanisms of Depression in CVDR01HL088726 · NHLBI · EMORY UNIVERSITY · PI BREMNER, JAMES DOUGLAS · 2008 to 2012
$2.6M
Biological Correlates of Traumatic StressK24MH076955 · NIMH · EMORY UNIVERSITY · PI BREMNER, JAMES DOUGLAS · 2006 to 2013
$946k
Emotional Stress as a Risk Factor for Arrhythmia: Ischemic and Genetic MechanismsK23HL127251 · NHLBI · EMORY UNIVERSITY · PI SHAH, AMIT JASVANT · 2016 to 2019
$749k
NCATS NIH HHS KL2 TR000455NCATS NIH HHS UL1 TR000454NCATS NIH HHS UL1 TR002378NHLBI NIH HHS K23 HL127251NHLBI NIH HHS R01 HL088726NIMH NIH HHS K24 MH076955NIMH NIH HHS R01 MH056120
6 · The paper itself

Abstract

backgroundThe mechanisms by which psychological factors may influence possibly arrhythmia risk are not known. We hypothesized that psychological wellness, measured by the General Well-Being Schedule (GBWS), is associated with less repolarization heterogeneity as measured by T-axis. We also explored whether T-axis was a mediator in the relationship of GWBS with adverse cardiac outcomes.

methodsWe studied 5533 adults aged 25-74 years without a history of CVD from NHANES I (National Health and Nutrition Examination Survey) (1971-75). Frontal T-axis was obtained through 12-lead ECG and characterized as normal (15° to 75°), borderline (-15° to 15° or 75° to 105°) or abnormal (>105° or <-15°).

resultsThe mean ± SD age was 43.1 ± 11.5 years and 55% were women. A 1-SD increase in GWBS score associated with a 23% reduced odds of abnormal T-axis (p < 0.001) and 11% lower hazard of composite CHD hospitalization and death (p = 0.02). When adjusting for sociodemographic factors, health behaviors, and CHD risk factors, the association was minimally changed and remained statistically significant. Additional adjustment for T-axis did not change the relationship with outcomes.

conclusionGeneral well-being is independently associated with less abnormal frontal T-axis and CHD events in otherwise healthy individuals.

Indexed as

Health StatusAdultAgedCardiovascular DiseasesCross-Sectional StudiesElectrocardiographyFemaleHealth BehaviorHumansMaleMiddle AgedNutrition SurveysSelf ReportCardiac repolarizationCoronary heart diseasePsychological well-being

Identifiers

PMID29735423
PMCPMC5994381

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.