Evidence map›Paper›PMID 29734795›Full record

ReviewNanomaterials (Basel, Switzerland)2018

Recommendations for In Vitro and In Vivo Testing of Magnetic Nanoparticle Hyperthermia Combined with Radiation Therapy.

Spiridon V Spirou, Sofia A Costa Lima, Penelope Bouziotis, Sanja Vranješ-Djurić, Eleni Κ Efthimiadou, Anna Laurenzana, Ana Isabel Barbosa, Ignacio Garcia-Alonso, Carlton Jones, Drina Jankovic and 1 more

Abstract readReview
In one paragraph

Review in Nanomaterials (Basel, Switzerland), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed.

  1. Review
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  9. FeNanomaterials (Basel, Switzerland) · 2022
    Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Magnetism in drug delivery: The marvels of iron oxides and substituted ferrites nanoparticles.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2020
    Review
  16. Polyol-Made Luminescent and Superparamagnetic β-NaYNanomaterials (Basel, Switzerland) · 2020
    Article
  17. Article
  18. Review
  19. Nanophosphor-Based Contrast Agents for Spectral X-ray Imaging.Nanomaterials (Basel, Switzerland) · 2019
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Spiridon V SpirouDepartment of Radiology, Sismanoglio General Hospital of Attica, Sismanogliou 1, Marousi 15126, Athens, Greece. spiridonspirou@yahoo.com.ORCID 0000-0003-3487-389X
Sofia A Costa LimaLAQV, REQUIMTE, Departamento de Ciências Químicas, Faculdade de Farmácia, Universidade do Porto, Porto 4050-313, Portugal. slima@ff.up.pt.
Penelope BouziotisInstitute of Nuclear & Radiological Sciences & Technology, Energy & Safety, National Center for Scientific Research "Demokritos", Aghia Paraskevi, Athens 15310, Greece. bouzioti@rrp.demokritos.gr.
Sanja Vranješ-Djurić"Vinča" Institute of Nuclear Sciences, University of Belgrade, Belgrade 11351, Serbia. sanjav@vinca.rs.
Eleni Κ EfthimiadouInorganic Chemistry Laboratory, Chemistry Department, National and Kapodistrian University of Athens, Panepistimiopolis, Zografou 15784, Greece. efthim@chem.chem.uoa.gr.
Anna LaurenzanaDepartment of Biomedical and Clinical Science "Mario Serio", University of Florence, 50134 Firenze, Italy. anna.laurenzana@unifi.it.
Ana Isabel BarbosaLAQV, REQUIMTE, Departamento de Ciências Químicas, Faculdade de Farmácia, Universidade do Porto, Porto 4050-313, Portugal. up200800307@ff.up.pt.
Ignacio Garcia-AlonsoDepartment of Surgery, Radiology & Ph.M. University of the Basque Country, Bilbao E48940, Spain. ignacio.galonso@ehu.es.ORCID 0000-0002-3701-1761
Carlton JonesNanoTherics Ltd., Studio 3, Unit 3, Silverdale Enterprise Centre Kents Lane, Newcastle under Lyme ST5 6SR, UK. carl.jones@nanotherics.com.
Drina Jankovic"Vinča" Institute of Nuclear Sciences, University of Belgrade, Belgrade 11351, Serbia. drinaj@vinca.rs.
Oliviero L GobboSchool of Pharmacy and Pharmaceutical Sciences, Panoz Institute, Trinity College Dublin, D02PN40 Dublin, Ireland. ogobbo@tcd.ie.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Magnetic nanoparticle (MNP)-mediated hyperthermia (MH) coupled with radiation therapy (RT) is a novel approach that has the potential to overcome various practical difficulties encountered in cancer treatment. In this work, we present recommendations for the in vitro and in vivo testing and application of the two treatment techniques. These recommendations were developed by the members of Working Group 3 of COST Action TD 1402: Multifunctional Nanoparticles for Magnetic Hyperthermia and Indirect Radiation Therapy ("Radiomag"). The purpose of the recommendations is not to provide definitive answers and directions but, rather, to outline those tests and considerations that a researcher must address in order to perform in vitro and in vivo studies. The recommendations are divided into 5 parts: (a) in vitro evaluation of MNPs; (b) in vitro evaluation of MNP-cell interactions; (c) in vivo evaluation of the MNPs; (d) MH combined with RT; and (e) pharmacokinetic studies of MNPs. Synthesis and characterization of the MNPs, as well as RT protocols, are beyond the scope of this work.

Indexed as

animal modelsbiodistributionin vitro assaysin vivo evaluationmagnetic nanoparticlespharmacokinetics

Identifiers

PMID29734795
PMCPMC5977320

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.